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Articles list with the same subject [entr] of Virologica Sinica
NAP1L1 has been shown to function in the life cycle of several DNA virus and retrovirus. However, whether NAP1L1 regulates hepatitis C virus (HCV), a positive-stranded RNA virus, remain to be elucidated. In this study, we identified NAP1L1 as a novel binding partner for HCV NS3. Our results suggest ..., Abstract
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Severe fever with thrombocytopenia syndrome virus (SFTSV) is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry ..., Abstract
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Hepatitis A virus is a pathogen associated with water pollution. Contaminated drinking water can cause hepatitis A outbreaks, lead to economic losses, and even threaten human lives. It is difficult to detect low levels of hepatitis A virus in water, so the virus must be concentrated in order to ..., Abstract
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The surface glycoproteins of coronaviruses play an important role in receptor binding and cell entry. Different coronaviruses interact with their specific receptors to enter host cells. Lentiviruses pseudotyped with their spike proteins (S) were compared to analyze the entry efficiency of ..., Abstract
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Viruses in the family Reoviridae are non-enveloped particles comprising a segmented double-stranded RNA genome surrounded by a two-layered or multi-layered icosahedral protein capsid. These viruses are classified into two sub-families based on their particle structural organization. Recent studies ..., Abstract
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Ebola virus infection causes severe hemorrhagic fever in human and non-human primates with high mortality. Viral entry/infection is initiated by binding of glycoprotein GP protein on Ebola virion to host cells, followed by fusion of virus-cell membrane also mediated by GP. Using an human ..., Abstract
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The glycoprotein (GP) of Ebola is the sole structural protein that forms the spikes on the viral envelope. The GP contains two subunits, GP1 and GP2, linked by a disulfide bond, which are responsible for receptor binding and membrane fusion, respectively. In this study, the full length of GP gene ..., Abstract
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The henipaviruses, represented by Nipah virus and Hendra virus, are emerging zoonotic viral pathogens responsible for repeated outbreaks associated with high morbidity and mortality in Australia, Southeast Asia, India and Bangladesh. These viruses enter host cells via a class I viral fusion ..., Abstract
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Kaposi’s sarcoma-associated herpesvirus (KSHV) was first identified as the etiologic agent of Kaposi’s sarcoma (KS) in 1994. KSHV infection is necessary, but not sufficient for the development of Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). ..., Abstract
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Heparan sulfate (HS); Herpesviruses; Herpes simplex virus type-1 (HSV-1); 3-O-sulfotransferases; Viral entry, Abstract
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Hepatitis C virus (HCV) is a member of the Flaviviridae family and causes acute and chronic hepatitis. Chronic HCV infection may result in severe liver damage including liver cirrhosis and hepatocellular carcinoma. The liver is the primary target organ of HCV, and the hepatocyte is its primary ..., Abstract
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Studies of the mechanism of HIV entry and transmission have identified multiple new targets for drug development. A range of inhibitors have demonstrated potent antiretroviral activity by interfering with CD4-gp120 interaction, coreceptor binding or viral-cell fusion in preclinical and clinical ..., Abstract
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Kaposi’s sarcoma-associated herpesvirus (KSHV) is the primary etiological agent of Kaposi’s sarcoma, primary effusion lymphoma and muticentric Castleman’s disease. In common with the other herpesviruses, KSHV exhibits both latent and lytic life cycles, both of which are characterized by distinct ..., Abstract
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Hepatitis B virus core antigen protein gene (C gene) was expressed in Saccharomyces cerevisiae and the products (rHBcAg particles) were purified from crude lysate of the yeast by three steps: Sephrose CL-4B chromatography, sucrose step-gradient ultracentrifugation, and CsCl-isopycnic ..., Abstract
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It is very important to optimize the operating conditions of virus concentration from water body for evaluating virus’s pollution and removing efficiency. In this paper, an optimizing method of virus concentration from water body was established. It was to adopt the way of throwing clay of ..., Abstract
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Abastract:Most of the cyanophages were adsorbed onto the ultrafilter membrance when pre—filtrated
water sample passed through the tangential flow ultrafiltration system.In order to recover much more
cyanophages,we used a technique named‘‘backflushing ultrafiltration”.The results ..., Abstract
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Abstract:The envelope proteins of White spot syndrome virus(WSSV)are very fragile and easy to be
destroyed during purification.It was difi cult to obtain a large quan tity of intact virions by routine
sucrose gradient centrifugation.After modifying the sucrose gradient by adding citrate ..., Abstract
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A pair of primers were designed and synthesized according to the reported S1 spike protein gene sequence of IBV.The viral RNA of SD/97/02 strain was amplified by reverse transcription polymerase chain reaction(RT PCR).The amplified product was analyzed by agarose gel electrophoresis,all appeared a ..., Abstract
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Japanese Encephalitis (JE) Vaccine in Vero cell can be easily purified by zonal centrifugation at non continuous sucrose gradients (36% and 60%), 32 600g for 4h. The calf serum protein and other nonviral proteins in the vaccine were almost separated from the JE virus. The residual calf serum ..., Abstract
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This study analyzed the configurational changes of poliovirus as it crossed the membrane of cells,and investigated the relationship between the configuration changes of this virus and its entryinto cells,The function of VP4 in the process of poliovirus entry into cells was studied also.Amodel about ..., Abstract
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