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Articles list with the same subject [hepatitis C virus (HCV)] of Virologica Sinica
Histone Deacetylase 3 Inhibitor Suppresses Hepatitis C Virus Replication by Regulating Apo-A1 and LEAP-1 Expression
Yuan Zhou, Qian Wang, Qi Yang, Jielin Tang, Chonghui Xu, Dongwei Gai, Xinwen Chen, Jizheng Chen
Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV) replication in Huh7 human liver cells and in a mouse model of HCV ..., Abstract
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2018 Vol. 33 (5): 418
KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China
Song Hu, Fahu Yuan, Lingyan Feng, Fang Zheng, Feili Gong, Hanju Huang, Binlian Sun
Natural killer (NK) cells play an important role in innate immunity to hepatitis C virus (HCV), especially in response to HCV infections. Killer cell immunoglobulin-like receptors (KIRs) are the primary receptors of NK cells that regulate NK cell behavior to antivirus infection response. Our aim ..., Abstract
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2018 Vol. 33 (4): 369
Hepatitis C in Laos: A 7-Year Retrospective Study on 1765 Patients
Phimpha Paboriboune, Thomas Vial, Philavanh Sitbounlang, Stéphane Bertani, Christian Trépo, Paul Dény, Francois-Xavier Babin, Nicolas Steenkeste, Pascal Pineau, Eric Deharo
Hepatitis C (HCV) is a global health concern, notably in Southeast Asia, and in Laos the presentation of the disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1,765 patients formerly ..., Abstract
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2018 Vol. 33 (4): 295
NAP1L1 Regulates Hepatitis C Virus Entry and Interacts with NS3
Peiqi Yin, Ye Li, Liya Zhou, Leiliang Zhang
NAP1L1 has been shown to function in the life cycle of several DNA virus and retrovirus. However, whether NAP1L1 regulates hepatitis C virus (HCV), a positive-stranded RNA virus, remain to be elucidated. In this study, we identified NAP1L1 as a novel binding partner for HCV NS3. Our results suggest ..., Abstract
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2018 Vol. 33 (2): 205
Hepatitis C virus-induced prion protein expression facilitates hepatitis C virus replication
Huixia Zhang, Shanshan Gao, Rongjuan Pei, Xinwen Chen, Chaoyang Li
Hepatitis C virus (HCV) infects approximately 180 million people worldwide. Significant progress has been made since the establishment of in vitro HCV infection models in cells. However, the replication of HCV is complex and not completely understood. Here, we found that the expression of ..., Abstract
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2017 Vol. 32 (6): 503
mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines
Li He, Aiping Zang, Min Du, Dapeng Ma, Chuanping Yuan, Chun Zhou, Jing Mu, Huanjing Shi, Dapeng Li, Xulin Huang, Qiang Deng, Jianhua Xiao, Huimin Yan, Lijian Hui, Ke Lan, Sidong Xiong, Xiaoxia Li, Zhong Huang, Hui Xiao
Although IL-12 plays a critical role in priming Th1 and cytotoxic T lymphocyte (CTL) responses, Toll-like receptor (TLR) signaling only induces low amounts of IL-12 in dendritic cells and macrophages, implying the existence of stringent regulatory mechanisms. In this study, we sought to uncover ..., Abstract
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2015 Vol. 30 (3): 174-189
Interleukin-12 as a Genetic Adjuvant Enhances Hepatitis C Virus NS3 DNA Vaccine Immunogenicity
Malihe Naderi, Atefeh Saeedi, Abdolvahab Moradi, Mishar Kleshadi, Mohammad Reza Zolfaghari, Ali Gorji, Amir Ghaemi
Hepatitis C virus (HCV) chronic infection is a worldwide health problem, and numerous efforts have been invested to develop novel vaccines. An efficient vaccine requires broad immune response induction against viral proteins. To achieve this goal, we constructed a DNA vaccine expressing ..., Abstract
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2013 Vol. 28 (3): 167-173
Regulation of Hepatitis C Virus Replication and Gene Expression by the MAPK-ERK Pathway
Rongjuan Pei, Xiaoyong Zhang, Song Xu, Zhongji Meng, Michael Roggendorf
The mitogen activated protein kinases-extracellular signal regulated kinases (MAPK-ERK) pathway is involved in regulation of multiple cellular processes including the cell cycle. In the present study using a Huh7 cell line Con1 with an HCV replicon, we have shown that the MAPK-ERK pathway plays a ..., Abstract
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2012 Vol. 27 (5): 278
HIV and HCV: from Co-infection to Epidemiology, Transmission, Pathogenesis, and Treatment
Lei KANG, Jing HU, Xue-shan XIA, and Jian-guo WU
Human immunodeficiency virus (HIV) is the infectious agent causing acquired immu- nodeficiency syndrome (AIDS), a deadliest scourge of human society. Hepatitis C virus (HCV) is a major causative agent of chronic liver disease and infects an estimated 170 million people worldwide, resulting in a ..., Abstract
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2007 Vol. 22 (6): 443-450
Effect of Hepatitis C Virus Core Protein on Interferon-Induced Antiviral Genes Expression and Its Mechanisms
Yan-zi CHANG, Yan-chang LEI, Wen WU, Shan-shan CHEN, Han-ju HUANG, Dong-liang YANG, Meng-ji LU
Emerging data indicated that HCV subverts the antiviral activity of interferon (IFN); however, whether HCV core protein contributes to the process remains controversial. In the present study, we examined the effect of HCV core protein on interferon-induced antiviral gene expression and whether the ..., Abstract
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2007 Vol. 22 (5): 374-379
The Relationship of the Nucleic Acid and Antibody of HIV/HCV Among Drug Users
ZHANG Chun-tao, LI Ai-hua, SONG Ai-jing, XU Si-hong, WANG You-chun
The objective of this study was to determine the relationship between the nucleic acid and antibody of HIV/HCV in a high-risk population. Plasma samples (320) were collected from drug users in Xinjiang and the nucleic acid and antibody of HIV/HCV were detected. A total of 38% of the subjects were ..., Abstract
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2005 Vol. 20 (6): 600-602
Hepatitis C Virus Non-structural Protein 4B Induces Unfolded Protein Response
ZHENG Yi, GAO Bo, KONG Ling-bao, YANG Xiao-jun, WU Zheng-hui, YE Yin-bai
The unspliced and spliced forms of XBP1 stably expressing NS4B in HeLa cells, the transcriptional levels of ATF6, Grp78 and caspase-12, and the luciferase activity in XBP1 and Grp78 promoter reporter assays in HeLa and Huh-7 cells expressing NS4B were detected. The results showed that the two forms ..., Abstract
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2005 Vol. 20 (4): 374-378
Expression of HCV Structural Proteins and Self-assembly of HCV-like Particles in Insect Cells
WANG Rui-qing, LIANG Chang-yong, JIAO Cheng-song, SONG Jian-hua, CHEN Xin-wen
Using a pair of specific primers designed according to the nucleotide sequence of Japanese encephalitis virus and Hameoaggulatinin of Human influenza virus from GenBank, the gene of JEV E protein’s main antigenic domain including the sequence of Human influenza virus ha gene was amplified with PCR ..., Abstract
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2005 Vol. 20 (1): 5-10
Purification and Enzymatic Analysis of the Recombinant Hepatitis C Virus NonStructure Protein 3 with Protease and Helicase Activity
LI Ti-yuan, XU Yi-ying, Kevin Philips
To study the enzymatic activity，the recombinant HCV NS3 protein with both protease and helicase activity was expressed and purified. The nonstructure gene 3 (NS3) of HCV was amplified and inserted into plasmid pPIC9 and the recombinant plasmid pPIC-NS3 was transformed into Pichia pastoris strain ..., Abstract
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2004 Vol. 19 (4): 325-328
A Skewed Light Chain Isotype Expression and B-Cell Clonal Dominance of Anti-HCV Response in Hepatitis C Virus Infection
TANG Shi-Xing, WANG Hai-Tao, BAO Zuo-Yi, ZHANG Xi-Tan
In antigen capture ELISA in which HCV peptides NS4 CP1 and CP2 derived from Hcv NS4and core gene region,respectively,were used as solid-phase antigens was developed to detect the differences in light chain isotype expresslion of anti-HCV antibodies. Antibodies in 65 sera of HCV infectedprofessional ..., Abstract
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1995 Vol. 10 (2): 141
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