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Gao et al., 2014(2), Virologica Sinica
at :2015/7/10 9:31:27    


Figure 1. Morpholgical feature (A-D) and morphogenesis (E-P) of H7N9 avian influenza virus. A: Negatively stained virions grown in chicken eggs showing spherical or ovoid particles with distinct surface spikes; B-C: Spherical (double arrow), ovoid (arrowhead) or filamentous (arrow) virus particles with prominent projections grown in MDCK cells; D: Spherical (double arrow), ovoid (arrowhead) or filamentous (arrow) virus particles with prominent projections grown in human lung explants. E: Virus particles budding at an early stage (1), budding at a later stage (2) from human lung explants cell surface and extracellular viral particles (3); F: Virus particles budding from microvilli of human lung explant cell (arrow); G-H: Budding or released virus particles in alveolar space (arrow); I-J: Virus particles located in human lung explant intercellular space (arrow); K: Virus particles on type II pneumocytes (arrow); L: Numerous tubular structures and dense rod-like structures present in H7N9 virus-infected pneumocytes each of which were of various lengths (tetragon). (Dashed line indicates nucleus border); M: Tubular structures with smooth outer edge (arrow) and cross-sections (arrowhead) in cytoplasm; N: Rod-like structures with a dense exterior (arrow) and cross-sections of tubules (arrowhead) in nulcleus; O: Rod-like structures with rough outer edges and striations perpendicular to the long axis in nulcleus (double arrow); P: Sieve-like structure (asterisk) in the cytoplasm of a pneumocyte. MV, microvilli;AS, alveolar space; IS, intercellular space; II, type II pneumocytes; Cyt, cytoplasm; Nu, nucleus.
 
VIROLOGICA SINICA 2014, 29(2): 123-125
DOI 10.1007/s12250-014-3384-3


LETTER


Ultrastructural characterization of avian influenza A (H7N9) virus infecting humans in China

 
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