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Cover image, 2014(5), Virologica Sinica
at :2015/7/9 9:00:21    

Varicella zoster virus (VZV) causes varicella (chicken pox) and herpes zoster (shingles). The current varicella vaccine (v-Oka) is highly attenuated in the skin, yet retains its neurovirulence and may reactivate and damage sensory neurons. Thus, the neuro-attenuated vaccine is in a great demand. In this issue, Silver and Zhu provide us a comprehensive review on the development of a genetically-defined live-attenuated VZV vaccine which could prevent neuronal and latent infection. The cover image shows the syncytia formation in VZV-infected ARPE-19 cells. Cells were infected with GPF-VZV, stained with WGA-Alexa Fluor 594 probe (red) for cell membrane, and DAPI (blue) for nuclei. (The microscopy image is provided by Dr. Hua Zhu, Rutgers-New Jersey Medical School, USA.)

Hua Zhu related reviews:

VIROLOGICA SINICA 2014, 29(5): 265-273
DOI 10.1007/s12250-014-3516-9



VIROLOGICA SINICA 2014, 29(6): 327-342
DOI 10.1007/s12250-014-3539-2


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