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研究人员揭示华中地区H5N6禽流感病毒的发生和演化特征
at :2017/4/18 9:58:51    

自2013年H5N6亚型禽流感病毒首次在中国出现以来,该病毒已造成一定的人员伤亡,对公共健康构成了潜在的威胁。为进一步了解人感染H5N6前环境病毒的演化特征,中国科学院武汉病毒研究所崔杰课题组开展了华中地区H5N6病毒的演化模式的研究,并取得重要进展,相关研究成果已在线发表在病毒学权威杂志Journal of Virology上。标题为“Molecular Evolution and Emergence of H5N6 Avian Influenza Virus in Central China”。

 

世界卫生组织于2016年11月报道了一例人在华中地区一活禽市场环境感染H5N6亚型禽流感病毒的病例。研究人员针对该地区2014-2015年活禽市场周围环境中H5N6病毒流行状况进行研究,建立了一系列病毒发生和演化的动态模型,分析发现该地区在人感染H5N6之前,环境中病毒的动力学较复杂,出现了至少6种病毒重配现象,包括属于2.3.2旧分支的HA基因引起的重配,并且分化成至少4种独立演化的支系,在当地流行。这些研究结果对人感染禽流感病毒的预警提供了独特见解。

 


 图:我国中部地区环境中H5N6亚型禽流感病毒重配动力图。


武汉病毒所病毒生物信息学学科组的杜英英为本文第一作者,崔杰研究员为通讯作者。本研究受国家重点研发计划、中国科学院率先行动“百人计划”资助。

 

ABSTRACT

H5N6 avian influenza virus (AIV) has posed a potential threat to public health since its emergence in China in 2013. To understand the evolution and emergence of H5N6 in the avian population we performed molecular surveillance of live poultry markets (LPMs) in Wugang prefecture, Hunan province, in central China during 2014-2015. Wugang prefecture is located on the Eastern Asian-Australian migratory bird flyway and a human death due to an H5N6 virus was reported in the prefecture on 21th November 2016. In total, we sampled and sequenced the complete genomes of 175 H5N6 AIVs. Notably, our analysis revealed that H5N6 contains at least six genotypes arising from segment reassortment, including a rare variant that possesses an HA gene derived from H5N1 clade 2.3.2 and a novel NP gene that has its origins with H7N3 viruses. In addition, phylogenetic analysis revealed that genetically similar H5N6 AIVs tended to cluster according to their geographic region of origin. These results help reveal the evolutionary behavior of influenza viruses prior to their emergence in humans.

IMPORTANCE The newly emerged H5N6 influenza A virus has caused more than ten human deaths in China since 2013. In November 2016 a human death due to H5N6 was confirmed by the WHO in Wugang prefecture, Hunan province. To better understand the evolution and emergence of H5N6 we surveyed live poultry markets (LPMs) in Wugang prefecture before the reported human death, with a focus on revealing the diversity and genomic origins of H5N6 in birds during 2014-2015. In general, H5N6 viruses in this region were most closely related to H5N1 clade 2.3.4.4, with the exception of one virus with an HA gene derived from clade 2.3.2 such that it represents a novel reassortant. Clearly, the ongoing surveillance of LPMs is central to monitoring the emergence of pathogenic influenza viruses.

原文链接:http://jvi.asm.org/content/early/2017/04/06/JVI.00143-17.abstract

 
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