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Special Issues of Virologica Sinica
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The newly emerged mosquito-borne Zika virus (ZIKV) has posed a global threat to human health. Several ZIKV vaccine candidates have been developed, and demonstrated to be efficacious in preclinical studies in mice and nonhuman primates. In this issue, Shiyu Dai et al. report a new virus-like particle (VLP) ZIKV vaccine based on the baculovirus expression system. Those VLPs demonstrate good immunogenicity in immunized mice, as they stimulate high levels of virus neutralizing antibody titers, ZIKV-specific IgG titers and potent memory T cell responses. The cover is adopted from an electron micrograph of negative staining baculovirus-expressed ZIKV VLPs (kindly provided by Fei Deng) with artistic processing. See page 213–226 for details., Read More >>
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