Special Issues of Virologica Sinica
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Viral pathogens frequently hijack the host actin polymerization machinery to facilitate their infection. Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) is one of the unique insect virus that inducing actin polymerization occurring in the nucleus, which requires relocation of cytoplasmic actin polymerization machinery, including actin-related protein 2/3 complex (Arp2/3), to the nucleus. Therefore, the alphabaculovirus-infection system could serve as a research model for investigating the nuclear import mechanism of Arp2/3. In this issue, Wang et al. investigated the spatial changes of Arp2/3 subunits induced by the viral replication-associated protein Ac34 in Sf9 cells. The cover shows the relocation of Arp2/3 subunits (P40, Arp2, ..., Read More >>
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