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Special Issue on Herpesviruses and Antiviral Strategies
This special issue is dedicated to the recent research progress on human
herpesviruses (HHVs). Human herpesviruses are distributed worldwide, and
more than 90% of adults are infected by one or multiple HHVs. The HHV family
contains three sub-families: the alpha sub-family [herpes simplex virus 1 (HSV-1),
HSV-2, and varicella-zoster virus (VZV)], beta sub-family [human cytomegalovirus
(HCMV), HHV6, and HHV7)], and gamma sub-family. [Epstein-Barr virus
(EBV) and Kaposi’s sarcoma–associated herpesvirus (KSHV)]. All the viruses
typically establish latent infection in host, and undergo lytic reactivation in certain
pathophysiological conditions. In this issue, we collectively present ten articles
focusing on the epidemiology, pathogenesis, and interventions of HSV-1, VZV,
HCMV, EBV and KSHV respectively, and these high-quality review and research
articles are contributed by experts on those specific viruses.
Current Issue: Vol.32 ( Oct 2017)
Editorial
In this issue, we collectively present ten articles focusing on the epidemiology,
pathogenesis, and interventions of HSV-1, VZV, HCMV, EBV and KSHV respectively, and these high-quality review and research articles are contributed by experts
on those specific viruses., Abstract
Review
Herpesviruses are remarkable pathogens that have evolved multiple mechanisms to evade host
immunity, ensuring their proliferation and egress. Among these mechanisms, herpesviruses utilize
elaborate extracellular vesicles, including exosomes, for the intricate interplay between infected
host and ..., Abstract
Review
Activation of specific sets of protein kinases by intracellular signal molecules has become more
and more apparent in the past decade. Phosphorylation, one of key posttranslational modification
events, is activated by kinase or regulatory protein and is vital for controlling many ..., Abstract
Review
Lipids are essential for mammalian cells to maintain many physiological functions. Emerging
evidence has shown that cancer cells can develop specific alterations in lipid biosynthesis and
metabolism to facilitate their survival and various malignant behaviors. To date, the precise role ..., Abstract
Review
Human cytomegalovirus (HCMV), a herpesvirus, is an important human pathogen that causes
asymptomatic infections in healthy or immunocompetent individuals but can lead to severe and
potentially life-threatening complications in immune-immature individuals such as neonates or
immune-compromised ..., Abstract
Research Article
Varicella-zoster virus (VZV) is a neurotropic alphaherpesvirus that causes chickenpox and
shingles. ORF7 is an important virulence determinant of VZV in both human skin and nerve tissues,
however, its specific function and involved molecular mechanism in VZV pathogenesis remain
largely elusive. ..., Abstract
Research Article
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent associated with
Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease. It has
been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated
KS are ..., Abstract
Research Article
We previously constructed a herpes simplex virus 1 (HSV-1) UL7 mutant virus (M1) and showed
that a partial deletion mutation of the UL7 gene led to a lower proliferative rate and an attenuated
phenotype. Using the M1 mutant, we further modified the UL41 gene, which encodes ..., Abstract
Research Article
Intravenous drug users (IDUs) have been demonstrated to be highly vulnerable to HIV/AIDS.
Nevertheless, the prevalence of Kaposi’s sarcoma associated herpesvirus (KSHV), an important
co-infected agent with HIV, among this population remained obscure. We conducted a systematic
review on the ..., Abstract
Research Article
Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, the etiology of which
remains unclear. It has been speculated that the immunopathogenesis of RE involves damage to
neurons, which eventually leads to the occurrence of RE. Viral infection may be a critical factor ..., Abstract
Research Article
Viruses commonly create favorable cellular conditions for their survival through multiple
mechanisms. MicroRNAs (miRNAs), which function as post-transcriptional regulators, are utilized
by human cytomegalovirus (HCMV) in its infection and pathogenesis. In the present study, the DNA
replication ..., Abstract
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