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Special Issue on Phage and Therapy
Editor(s): HongPing Wei, PhD, Professor
Wuhan Institute of Virology, China
This issue of Virologica Sinica is to celebrate the 100th anniversary of
the discovery of “fi lterable lytic factor” or “bacteriophage” (1915-2015).
During the past 100 years, both basic knowledge and applications of
bacteriophages have been substantially explored and developed. In
recent years, bacteriophage research is booming and holding the hope
to tackle the rise of antimicrobial resistance in the post-antibiotic era.
In this issue, new phages are introduced, phage lytic enzymes are
described, phage and host interactions are discussed, and successful
experiences of phage therapy are shared. The cover illustrates the
phages in this issue: ΦVMY22 (golden yellow), ΦCASbig (orange red),
ΦKAZ14(magenta). And the phage in blue color is the courtesy of the
Core Facility of Wuhan Institute of Virology.
Editorial
The year 2015 marks 100 years since Dr. Frederick Twort discovered the “filterable lytic factor”, which was later independently discovered and named “bacteriophage” by Dr.Felix d'Herelle. On this memorable centennial, it is exciting to see a special issue published by Virologica Sinica on ..., Abstract
Review
Phages are credited with having been fi rst described in what we now, offi cially, are commemorating as the 100th. anniversary of their discovery. Those one-hundred years of phage history have not been lacking in excitement, controversy, and occasional convolution. One such complication ..., Abstract
Review
The Enterobacteriaceae are a class of gram-negative facultative anaerobic rods, which can cause a variety of diseases, such as bacteremia, septic arthritis, endocarditis, osteomyelitis, lower respiratory tract infections, skin and soft-tissue infections, urinary tract infections, intra-abdominal ..., Abstract
Review
The lysogenic phage CTXΦ of Vibrio cholerae can transfer the cholera toxin gene both horizontally (inter-strain) and vertically (cell proliferation). Due to its diversity in form and species, the complexity of regulatory mechanisms, and the important role of the infection mechanism in the ..., Abstract
Review
There are many recent studies regarding the efficacy of bacteriophage-related lytic enzymes: the enzymes of ‘bacteria-eaters’ or viruses that infect bacteria. By degrading the cell wall of the targeted bacteria, these lytic enzymes have been shown to efficiently lyse Gram-positive bacteria ..., Abstract
Research Article
The emergence of multidrug-resistant bacterial pathogens forced us to consider the phage therapy as one of the possible alternative approaches to treatment. The purpose of this paper is to consider the conditions for the safe, long-term use of phage therapy against various infections caused by ..., Abstract
Research Article
The novel phage lysin PlySs2, is reported to be highly active against various bacteria, including staphylococci, streptococci and Listeria. However, the molecular mechanisms underlying its broad lytic spectrum remain to be established. In the present study, the lytic activity of the catalytic ..., Abstract
Research Article
As a unique ecological system with low temperature and low nutrient levels, glaciers are considered a “living fossil” for the research of evolution. In this work, a lytic cold-active bacteriophage designated VMY22 against Bacillus cereus MYB41-22 was isolated from Mingyong Glacier in China, and ..., Abstract
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