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Special Issue on Structural Virology
Editor(s): Peng Gong, PhD, Professor
Wuhan Institute of Virology, China
A special topic section on Structural Virology is included in this issue. The section contains three review articles, which cover the recent research advancement on the structures of reovirus particle, flavivirus NS2B-NS3 protease, and enterophage T7 RNA polymerase. The issue cover presents: i) Crystal structure of a late initiation complex of T7 RNA Polymerase; ii) Crystal structure of the NS2B-NS3 protease with a peptide-based inhibitor; iii) Cryo-EM structure of the turreted reovirus core.
Flaviviruses are positive-sense RNA viruses, and many are important human pathogens. Nonstructural protein 2B and 3 of the flaviviruses (NS2BNS3) form an endoplasmic reticulum (ER) membraneassociated hetero-dimeric complex through the NS2B transmembrane region. The NS2BNS3 complex is ..., Abstract
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Viruses in the family Reoviridae are non-enveloped particles comprising a segmented double-stranded RNA genome surrounded by a two-layered or multi-layered icosahedral protein capsid. These viruses are classified into two sub-families based on their particle structural organization. Recent studies ..., Abstract
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Many flaviviruses are significant human pathogens causing considerable disease burdens, including encephalitis and hemorrhagic fever, in the regions in which they are endemic. A paucity of treatments for flaviviral infections has driven interest in drug development targeting proteins essential to ..., Abstract
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During transcription initiation, RNA polymerase binds tightly to the promoter DNA defining the start of transcription, transcribes comparatively slowly, and frequently releases short transcripts (3-8 nucleotides) in a process called abortive cycling. Transitioning to elongation, the second phase of ..., Abstract
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