Special Issue on Coronaviruses
Editor(s): Zheng-Li Shi; Deyin Guo; Peter J.M. Rottier
Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan; Wuhan University, Wuhan; Utrecht University, Utrecht
Coronaviruses (CoVs) infect a wide range of vertebrates, including humans. They can cause respiratory, gastrointestinal, hepatic and central nervous system diseases. Some CoVs have managed to across the species barrier, such as severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV. This special issue of Virologica Sinica is dedicated to the recent progress on coronaviruses and covers topics on viral epidemiology, virus replication and the interactions between the coronaviruses and their hosts. This updated information would provide new insights in the control of CoV infections, and in the development of effective antivirals. The cover depicts the modes of transmission of coronavirus from animals to humans.
This special issue of the journal is dedicated to the recent progress on coronaviruses and covers the topics of viral epidemiology, virus replication and the interactions between the coronaviruses and their hosts., Abstract
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The 5′-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose ..., Abstract
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Coronaviruses have been closely related with mankind for thousands of years. Communityacquired human coronaviruses have long been recognized to cause common cold. However, zoonotic coronaviruses are now becoming more a global concern with the discovery of highly pathogenic severe acute ..., Abstract
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Coronaviruses (CoVs) can cause highly prevalent diseases in humans and animals. The fatal outbreak of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) highlights the threat posed by this unique virus subfamily. However, no specific drugs have been approved to ..., Abstract
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Research Article
Since the 2002–2003 severe acute respiratory syndrome (SARS) outbreak prompted a search for the natural reservoir of the SARS coronavirus, numerous alpha- and betacoronaviruses have been discovered in bats around the world. Bats are likely the natural reservoir of alpha- and ..., Abstract
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Research Article
We conducted a six-year epidemiological study on human coronaviruses (HCoVs) circulating in Hong Kong, using 8275 nasopharyngeal samples from patients with acute respiratory tract infections. HCoVs were detected in 77 (0.93%) of the samples by a pan-HCoV RT-PCR assay. The most frequently ..., Abstract
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Research Article
The surface glycoproteins of coronaviruses play an important role in receptor binding and cell entry. Different coronaviruses interact with their specific receptors to enter host cells. Lentiviruses pseudotyped with their spike proteins (S) were compared to analyze the entry efficiency of ..., Abstract
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Research Article
Avian infectious bronchitis virus (IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune ..., Abstract
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Research Article
Bats have been implicated as important reservoir hosts of alpha- and betacoronaviruses. In this study, diverse coronaviruses (CoVs) were detected in 50 of 951 (positive rate 5.3%) intestinal specimens of eight bat species collected in four provinces and the Tibet Autonomous Region of China by ..., Abstract
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In previous studies, the authors have found diverse SARS-like coronaviruses (SL-CoVs) in a single bat colony. To investigate the spatio-temporal dynamics of these viruses, a longitudinal surveillance of bat SL-CoV from a total of 431 bat fecal samples collected during 2011 to 2014 from the Yunnan ..., Abstract
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To date, Middle East respiratory syndrome coronavirus (MERS-CoV) has affected over 1600 individuals in 26 countries across the globe, claiming 40% lives and thus poses a great public health challenge to the Middle East and elsewhere. Risk factors for mortality and severity among MERS patients are ..., Abstract
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In this study, the authors developed a two-tube multiplex real-time RT-PCR assay for sensitive and specific detection of all known human coronaviruses. Its ability to monitor HKU1 replication in cultures of human airway epithelial cells, to quantitatively measure viral RNA in monkeys experimentally ..., Abstract
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In this study, the authors evaluated Australian pilgrims’ knowledge and perceptions regarding the risk of MERS-CoV and camel contact at Hajj. Moreover, the authors assessed their practice regarding contact with camels during Hajj. This is the first study which has assessed the actual practice of ..., Abstract
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This manuscript was suggested to be re-organized, and considered to be published in the form of “perspective”. It’s suggested to be organized into four parts: Brief introduction of CoVs; prevalence of six human CoVs (especially the cases about the global transmission); the zoonotic origin; ..., Abstract
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