Figure 1个  Table 3个
    • Characteristic Patients
      ART naive
      (n=104)      		 ART failure
      (n=271)
      Age, years 32(14–50) 36(7–72)
      Sex
      Male 77(74.04) 193(71.23)
      Female 27(25.96) 78(28.78)
      Viral load, RNA, lg copies/mL 4.59(2.89–6.74) 4.51(1.70–6.27)
      Route of HIV infection
      Intravenous drug use 82(78.85) 109(40.22)
      Homosexual sex 22(21.15) 19(7.01)
      Heterosexual sex – 137(50.55)
      MTCT – 5(3.68)
      Other/unknown – 1(0.74)
      Duration of ART, years – 1.4(0.3–6)
      ART regimen(current used)
      3TC – 1(0.37)
      AZT – 1(0.37)
      d4T – 1(0.37)
      3TC/AZT/NVP – 157(57.93)
      3TC/d4T/NVP – 68(25.09)
      3TC/EFV/AZT – 16(5.90)
      3TC/EFV/d4T – 8(2.95)
      3TC/AZT/LPV/r – 1(0.37)
      3TC/TDF/EFV – 15(5.54)
      d4T/3TC/AZT/NVP – 3(1.11%)
      Results are presented as n (%) or median (interquartile range). Abbreviations: 3TC, lamivudine; ART, antiretroviral therapy; AZT, zidovudine; d4T, stavudine; EFV, efavirenz; LPV/r, lopinavir with ritonavir; MTCT, mother-to-child transmission; NVP, nevirapine; TDF, tenofovir.

      Table 1.  Demographic characteristics of study participants with HIV-1 CRF07_BC

    • Resistant to nucleoside reverse transcriptase inhibitors
      Frequency(%)      		 Resistant to non-nucleoside reverse transcriptase inhibitors
      Frequency(%)
      Mutation ART naive
      (n=104)      		 ART failure
      (n=271)      		 Mutation ART naive
      (n=104)      		 ART failure
      (n=271)
      M41L 0.00 2.45 V90I 0.00 1.96
      D67N/G 0.00 8.13 K101Q/E 0.00 7.64
      T69S/A 0.00 2.45 K103N 0.00 45.01
      K70R 0.00 4.28 V106M 0.00 8.13
      M184V/I 0.00 35.88 E138A 0.00 1.00
      T215Y/I 0.00 4.28 V179D/E 0.00 6.80
      K219E 0.00 4.28 Y181C 0.00 17.33
      Y188C/L 0.00 9.20
      G190S/A 0.00 15.88
      H221Y 0.00 1.44
      P225H 0.00 1.00
      F227L 0.00 1.44
      K238 0.00 2.84
      Abbreviation: ART, antiretroviral therapy.

      Table 2.  Drug-resistance mutations in the current populations among HIV variants epidemic in Sichuan province

    • Position Wild type
      (aa)      		 Mutation
      (aa)      		 Frequency(%) χ2 p-value
      ART naive ART failure
      28 E K 0.00 14.02 – –
      32 K E 1.90 15.50 13.37 < 0.01
      35 T M 1.90 7.94 3.96 < 0.05
      200 T A 4.76 12.92 5.18 < 0.05
      248 E V 0.00 10.70 – –
      248 E D 0.00 2.58 – –
      249 K Q 0.00 13.28 – –
      Abbreviation: ART, antiretroviral therapy.

      Table 3.  DrugMutations with significantly different distributions in the reverse transcriptase region between the therapy-naive (n=104) and ART-failure populations (n=271)