• Arita, M., Wakita, T., Shimizu, H., 2008. Characterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivity. J Gen Virol, 89, 2518-2530.

  • Bajaber, N., Ramanathan, B., 2021. Methods in Screening Antiviral Drugs Against Enterovirus 71. Methods Mol Biol, 2296, 167-184.

  • Bello, A.M., Roshorm, Y.M., 2022. Recent progress and advances towards developing enterovirus 71 vaccines for effective protection against human hand, foot and mouth disease (HFMD). Biologicals, 79, 1-9.

  • Bian, L., Gao, F., Mao, Q., Sun, S., Wu, X., Liu, S., Yang, X., Liang, Z., 2019. Hand, foot, and mouth disease associated with coxsackievirus A10:more serious than it seems. Expert Rev Anti Infect Ther, 17, 233-242.

  • Chopra, B., Dhingra, A.K., 2021. Natural products:A lead for drug discovery and development. Phytother Res, 10.1002/ptr.7099.

  • Deng, C., Li, X., Liu, S., Xu, L., Ye, H., Qin, C.F., Zhang, B., 2015. Development and characterization of a clinical strain of Coxsackievirus A16 and an eGFP infectious clone. Virol Sin, 30, 269-276.

  • Deng, C.L., Yeo, H., Ye, H.Q., Liu, S.Q., Shang, B.D., Gong, P., Alonso, S., Shi, P.Y., Zhang, B., 2014. Inhibition of enterovirus 71 by adenosine analog NITD008. J Virol, 88, 11915-11923.

  • Dong, S., Yu, R., Wang, X., Chen, B., Si, F., Zhou, J., Xie, C., Li, Z., Zhang, D., 2022. Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus In Vitro and In Vivo. Viruses 14, 1231.

  • Elshabrawy, H.A., Fan, J., Haddad, C.S., Ratia, K., Broder, C.C., Caffrey, M., Prabhakar, B.S., 2014. Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay. J Virol, 88, 4353-4365.

  • Fan, H., He, S.T., Han, P., Hong, B., Liu, K., Li, M., Wang, S., Tong, Y., 2022. Cepharanthine:A Promising Old Drug against SARS-CoV-2. Adv Biol (Weinh), 6, e2200148.

  • Guo, B., Su, J., Zhang, T., Wang, K., Li, X., 2015. Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. J Drug Target, 23, 266-274.

  • Huang, Y., Zhou, Y., Lu, H., Yang, H., Feng, Q., Dai, Y., Chen, L., Yu, S., Yao, X., Zhang, H., Jiang, M., Wang, Y., Han, N., Hu, G., He, Y., 2015. Characterization of severe hand, foot, and mouth disease in Shenzhen, China, 2009-2013. J Med Virol. 87, 1471-1479.

  • Kataoka, C., Suzuki, T., Kotani, O., Iwata-Yoshikawa, N., Nagata, N., Ami, Y., Wakita, T., Nishimura, Y., Shimizu, H., 2015. The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model. PLoS Pathog, 11, e1005033.

  • Kim, D.E., Min, J.S., Jang, M.S., Lee, J.Y., Shin, Y.S., Song, J.H., Kim, H.R., Kim, S., Jin, Y.H., Kwon, S., 2019. Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells. Biomolecules 9, 696.

  • Kinobe, R., Wiyatno, A., Artika, I.M., Safari, D., 2022. Insight into the Enterovirus A71:A review. Rev Med Virol, 32, e2361.

  • Kobayashi, K., Sudaka, Y., Takashino, A., Imura, A., Fujii, K., Koike, S., 2018. Amino Acid Variation at VP1-145 of Enterovirus 71 Determines Attachment Receptor Usage and Neurovirulence in Human Scavenger Receptor B2 Transgenic Mice. J Virol. 92, e00681-18.

  • Li, J.Q., Deng, C.L., Gu, D., Li, X., Shi, L., He, J., Zhang, Q.Y., Zhang, B., Ye, H.Q., 2018. Development of a replicon cell line-based high throughput antiviral assay for screening inhibitors of Zika virus. Antiviral Res, 150, 148-154.

  • Li, Q., Maddox, C., Rasmussen, L., Hobrath, J.V., White, L.E., 2009. Assay development and high-throughput antiviral drug screening against Bluetongue virus. Antiviral Res, 83, 267-273.

  • Liu, T., Liu, X., Li, W., 2016. Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy. Oncotarget, 7, 40800-40815.

  • Lu, W.W., Kung, F.Y., Deng, P.A., Lin, Y.C., Lin, C.W., Kung, S.H., 2017. Development of a fluorescence resonance energy transfer-based intracellular assay to identify novel enterovirus 71 antivirals. Arch Virol, 162, 713-720.

  • Martins Lima, A., Bragina, M.E., Burri, O., Bortoli Chapalay, J., Costa-Fraga, F.P., Chambon, M., Fraga-Silva, R.A., Stergiopulos, N., 2019. An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format. Platelets, 30, 563-571.

  • Newman, D.J., Cragg, G.M., 2016. Natural Products as Sources of New Drugs from 1981 to 2014. J Nat Prod, 79, 629-661.

  • Nishimura, Y., Lee, H., Hafenstein, S., Kataoka, C., Wakita, T., Bergelson, J.M., Shimizu, H., 2013. Enterovirus 71 binding to PSGL-1 on leukocytes:VP1-145 acts as a molecular switch to control receptor interaction. PLoS Pathog, 9, e1003511.

  • Saguil, A., Kane, S.F., Lauters, R., Mercado, M.G., 2019. Hand-Foot-and-Mouth Disease:Rapid Evidence Review. Am Fam Physician, 100, 408-414.

  • Sakurai, Y., Kolokoltsov, A.A., Chen, C.C., Tidwell, M.W., Bauta, W.E., Klugbauer, N., Grimm, C., Wahl-Schott, C., Biel, M., Davey, R.A., 2015. Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science, 347, 995-998.

  • Shan, L., Tong, L., Hang, L., Fan, H., 2019. Fangchinoline supplementation attenuates inflammatory markers in experimental rheumatoid arthritis-induced rats. Biomed Pharmacother, 111, 142-150.

  • Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P.Y., Zhang, B., 2013. Development and characterization of a stable eGFP enterovirus 71 for antiviral screening. Antiviral Research, 97, 198-205.

  • Sharma, V., Goessling, L.S., Brar, A.K., Eghtesady, P., 2023. Multiple subtypes of coxsackievirus group B can cause congenital heart disease. Birth Defects Res, 115, 171-178.

  • Ulferts, R., De Boer, S.M., Van Der Linden, L., Bauer, L., Lyoo, H.R., Mate, M.J., Lichiere, J., Canard, B., Lelieveld, D., Omta, W., Egan, D., Coutard, B., Van Kuppeveld, F.J., 2016. Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C. Antimicrob Agents Chemother, 60, 2627-2638.

  • Wan, Z., Lu, Y., Liao, Q., Wu, Y., Chen, X., 2012. Fangchinoline inhibits human immunodeficiency virus type 1 replication by interfering with gp160 proteolytic processing. PLoS One, 7, e39225.

  • Wang, C.D., Huang, J.G., Gao, X., Li, Y., Zhou, S.Y., Yan, X., Zou, A., Chang, J.L., Wang, Y.S., Yang, G.X., He, G.Y., 2010. Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft. Biosci Biotechnol Biochem, 74, 488-493.

  • Wang, J., Liu, J., Fang, F., Wu, J., Ji, T., Yang, Y., Liu, L., Li, C., Zhang, W., Zhang, X.,Teng, Z., 2022. Genomic surveillance of coxsackievirus A10 reveals genetic features and recent appearance of genogroup D in Shanghai, China, 2016-2020. Virol Sin, 37, 177-186.

  • Xi, J., Ma, C., Wei, Z., Yin, B., Zhao, S., Quan, W., Yang, J., Yuan, J., Qiang, B., Ye, F., Peng, X., 2021. A single mutation in the cis-acting replication element identified within the EV-A71 2C-coding region causes defects in virus production in cell culture. Emerg Microbes Infect. 10, 1988-1999.

  • Xing, Z., Zhang, Y., Zhang, X., Yang, Y., Ma, Y., Pang, D., 2013. Fangchinoline induces G1 arrest in breast cancer cells through cell-cycle regulation. Phytother Res, 27, 1790-1794.

  • Yin, Z., Chen, Y.L., Schul, W., Wang, Q.Y., Gu, F., Duraiswamy, J., Kondreddi, R.R., Niyomrattanakit, P., Lakshminarayana, S.B., Goh, A., Xu, H.Y., Liu, W., Liu, B., Lim, J.Y., Ng, C.Y., Qing, M., Lim, C.C., Yip, A., Wang, G., Chan, W.L., Tan, H.P., Lin, K., Zhang, B., Zou, G., Bernard, K.A., Garrett, C., Beltz, K., Dong, M., Weaver, M., He, H., Pichota, A., Dartois, V., Keller, T.H.,Shi, P.Y., 2009. An adenosine nucleoside inhibitor of dengue virus. Proc Natl Acad Sci U S A, 106, 20435-20439.

  • Zhang, M., Wang, H., Tang, J., He, Y., Xiong, T., Li, W., Qu, Y., Mu, D., 2021. Clinical characteristics of severe neonatal enterovirus infection:a systematic review. BMC Pediatr, 21, 127.

  • Zhang, Q., MacDonald, N. E., Smith, J. C., Cai, K., Yu, H., Li, H., Lei, C., 2014. Severe enterovirus type 71 nervous system infections in children in the Shanghai region of China:clinical manifestations and implications for prevention and care. Pediatr Infect Dis J. 33, 482-487.

  • Zhang, Q.Y., Deng, C.L., Liu, J., Li, J.Q., Zhang, H.Q., Li, N., Zhang, Y.N., Li, X.D., Zhang, B., Xu, Y., Ye, H.Q., 2021. SARS-CoV-2 replicon for high-throughput antiviral screening. J Gen Virol. 102, 001583.

  • Zhang, X., Zhang, Y., Li, H., Liu, L., 2022. Hand-Foot-and-Mouth Disease-Associated Enterovirus and the Development of Multivalent HFMD Vaccines. Int J Mol Sci. 24, 169.

  • Zhang, Y., Ke, X., Zheng, C., Liu, Y., Xie, L., Zheng, Z., Wang, H., 2017. Development of a luciferase-based biosensor to assess enterovirus 71 3C protease activity in living cells. Sci Rep, 7, 10385.

  • Zhang, Z., Yang, E., Hu, C., Cheng, H., Chen, C.Y., Huang, D., Wang, R., Zhao, Y., Rong, L., Vignuzzi, M., Shen, H., Shen, L., Chen, Z.W., 2017. Cell-Based High-Throughput Screening Assay Identifies 2',2'-Difluoro-2'-deoxycytidine Gemcitabine as a Potential Antipoliovirus Agent. ACS Infect Dis, 3, 45-53.

  • Zhang, Z.R., Zhang, Y.N., Zhang, H.Q., Zhang, Q.Y., Li, N., Li, Q., Deng, C.L., Zhang, B., Li, X.D., Ye, H.Q., 2022. Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion. PLoS Negl Trop Dis. 16, e0010363.