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Host Cell line Origin of cell line Expression of N protein at 24 hpia Cytopathic effect at 72hpib Bat RaLu# Rhinolophus. affinis lung ++++ N RsHe Rhinolophus. sinicus heart + N RlKi Rousettus leschenaultia kidney ++++ N PaKi Pteropus alecto kidney ++++ N Swine SIEC Sus scrofa intestine + N/D ST* S. scrofa testicle ++++ N IBRS S. scrofa kidney ++ P LLC-PK1* S. scrofa kidney + N Human A549* Homo sapiens lung ++ N HeLa* H. sapiens cervix + P Hep2 H. sapiens larynx ++ N RD H. sapiens embryonic ++++ N Monkey Vero* Chlorocebus aethiops kidney ++++ P LLC-MK2 Macaca mulatta kidney +++ N Cat FK Felinae kidney ++ N/D Dog MDCK* Canis familiaris kidney + N Mink Mv.1.Lu Mustla vison lung ++++ N Hamster BHK-21* Mesocricetus auratus kidney ++ N Rat BRL* Rattus norvegicus liver + N Mouse L929 Mus musculus lung + N The susceptibility of SADS-CoV in trypsin-treated cells was determined by expression of SADS-CoV N protein and Cytopathic effect.
aExpression efficiency of N protein is defined by green fluorescence positive cell ratio; +, 1%–5%; ++, > 5%–10%; +++, > 10%–25%; ++++, > 25%.
bP and N are defined as positive and negative, respectively. N/D, Not detected due to their sensitivity to trypsin.
*Cell lines have been tested for the susceptibility to SADS-CoV byYang et al. (2019) .
#The primary cell line established in our laboratory.Table 1. Cell lines derived from different hosts were tested for the susceptibility to SADS-CoV.
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Table 1 个
