• Alexopoulou, A., Karayiannis, P., 2014. HBeAg negative variants and their role in the natural history of chronic hepatitis B virus infection. World J Gastroenterol. 20, 7644-7652.

  • Bhukya, P.L., C, V.K., Lole, K.S., 2021. Transcriptome analysis of hepatoma cells transfected with Basal Core Promoter (BCP) and Pre-Core (PC) mutant hepatitis B virus full genome construct. J Gen Virol. 102.

  • Brunetto, M.R., Giarin, M., Saracco, G., Oliveri, F., Calvo, P., Capra, G., Randone, A., Abate, M.L., Manzini, P., Capalbo, M., Piantino, P., Verme, G., Bonino, F., 1993. Hepatitis B virus unable to secrete e antigen and response to interferon in chronic hepatitis B. Gastroenterology. 105, 845-50.

  • Choi, J.W., Ahn, S.H., Park, J.Y., Chang, H.Y., Kim, J.K., Baatarkhuu, O., Kim, D.Y., Han, K.H., Chon, C.Y., 2009. Hepatitis B e antigen-negative mutations in the precore and core promoter regions in Korean patients. J Med Virol. 81, 594-601.

  • Chu, C.M., Yeh, C.T., Lee, C.S., Sheen, I.S., Liaw, Y.F., 2002. Precore stop mutant in HBeAg-positive patients with chronic hepatitis B:clinical characteristics and correlation with the course of HBeAg-to-anti-HBe seroconversion. J Clin Microbiol. 40, 16-21.

  • Frelin, L., Wahlström, T., Tucker, A.E., Jones, J., Hughes, J., Lee, B.O., Billaud, J.N., Peters, C., Whitacre, D., Peterson, D., Milich, D.R., 2009. A mechanism to explain the selection of the hepatitis e antigen-negative mutant during chronic hepatitis B virus infection. J Virol. 83, 1379-92.

  • Geng, Y., Wang, X., Lu, X., Wu, X., Xu, N., Han, L., Xu, J., 2016. Mutation Changes in the preC/Core Promoter in HBeAg-Positive Patients With Chronic Hepatitis B During Interferon Therapy. Medicine (Baltimore). 95, e2657.

  • Guo, F., Zhao, Q., Sheraz, M., Cheng, J., Qi, Y., Su, Q., Cuconati, A., Wei, L., Du, Y., Li, W., Chang, J., Guo, J.T., 2017. HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways. PLoS Pathog. 13, e1006658.

  • Hayashi, S., Khan, A., Simons, B.C., Homan, C., Matsui, T., Ogawa, K., Kawashima, K., Murakami, S., Takahashi, S., Isogawa, M., Ikeo, K., Mizokami, M., McMahon, B.J., Tanaka, Y., 2019. An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People. Hepatology. 69, 19-33.

  • Iannacone, M., Guidotti, L.G., 2022. Immunobiology and pathogenesis of hepatitis B virus infection. Nat Rev Immunol. 22, 19-32.

  • Jammeh, S., Tavner, F., Watson, R., Thomas, H.C., Karayiannis, P., 2008. Effect of basal core promoter and pre-core mutations on hepatitis B virus replication. J Gen Virol. 89, 901-909.

  • Karousis, E.D., Muhlemann, O., 2019. Nonsense-Mediated mRNA Decay Begins Where Translation Ends. Cold Spring Harb Perspect Biol. 11.

  • Kawabe, N., Hashimoto, S., Harata, M., Nitta, Y., Murao, M., Nakano, T., Shimazaki, H., Arima, Y., Komura, N., Kobayashi, K., Yoshioka, K., 2009. The loss of HBeAg without precore mutation results in lower HBV DNA levels and ALT levels in chronic hepatitis B virus infection. J Gastroenterol. 44, 751-6.

  • Koumbi, L., Pollicino, T., Raimondo, G., Stampoulis, D., Khakoo, S., Karayiannis, P., 2016. Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status. Virus Res. 220, 150-160.

  • Kuipery, A., Gehring, A.J., Isogawa, M., 2020. Mechanisms of HBV immune evasion. Antiviral Res. 179, 104816.

  • Lau, D.T.Y., Ganova-Raeva, L., Wang, J., Mogul, D., Chung, R.T., Lisker-Melman, M., Chang, K.M., Shaikh, O.S., Janssen, H.L.A., Wahed, A.S., Lok, A.S., Hepatitis B Research Network, 2021. Precore and Basal Core Promoter Hepatitis B Virus (HBV) Variants Are Present From a Young Age and Differ Across HBV Genotypes. Hepatology. 73, 1637-1651.

  • Lee, K., Tirasophon, W., Shen, X., Michalak, M., Prywes, R., Okada, T., Yoshida, H., Mori, K., Kaufman, RJ., 2002. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16, 452-66.

  • Li, G., Zhu, Y., Shao, D., Chang, H., Zhang, X., Zhou, D., Gao, Y., Lan, K., Deng, Q., 2018. Recombinant covalently closed circular DNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model. Hepatology. 67, 56-70.

  • Liu, H., Cheng, J., Viswanathan, U., Chang, J., Lu, F., Guo, JT., 2021. Amino acid residues at core protein dimer-dimer interface modulate multiple steps of hepatitis B virus replication and HBeAg biogenesis. PLoS Pathog. 17, e1010057.

  • Malhi, H., Kaufman, RJ., 2011. Endoplasmic reticulum stress in liver disease. J Hepatol. 54:795-809.

  • Michailidis, E., Pabon, J., Xiang, K., Park, P., Ramanan, V., Hoffmann, HH., Schneider, W.M., Bhatia, S.N., de Jong, Y.P., Shlomai, A., Rice, C.M., 2017. A robust cell culture system supporting the complete life cycle of hepatitis B virus. Sci Rep. 7, 16616.

  • Moradzadeh, M., Tayebi, S., Poustchi, H., Sayehmiri, K., Shahnazari, P., Naderi, E., Montazeri, G., Mohamadkhani, A., 2013. The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation. Adv Virol. 2013, 780319.

  • Nakashima, H., Furusyo, N., Kubo, N., Kashiwagi, K., Etoh, Y., Kashiwagi, S., Hayashi, J., 2004. Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection. J Gastroenterol Hepatol. 19, 541-50.

  • Ouneissa, R., Bahri, O., Alaya-Bouafif, N.B., Chouaieb, S., Ben Yahia, A., Sadraoui, A., Hammami, W., Filali, N., Azzouz, M.M., Mami, N.B., Triki, H., 2012. Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B. J Med Virol. 84, 1719-1726.

  • Pan, C.Q., Dai, E., Bhamidimarri, K.R., Zeng, Z., Yin, P., 2017. Clinical Features of Chronic Hepatitis B in Treatment-naive Asian Patients With Positive HBeAg and Coexisting Precore and/or Basal Core Promoter Mutations. J Clin Gastroenterol. 51, 261-267.

  • Pivert, A., Servant-Delmas, A., Lunel-Fabiani, F., Le Guillou-Guillemette, H., Laperche, S., Ducancelle, A., 2015. Correlation between the promoter basal core and precore mutations and HBsAg quantification in French blood donors infected with hepatitis B virus. J Med Virol. 87, 529-535.

  • Qin, Y., Zhang, J., Mao, R., Guo, H., Yin, Y., Wu, X., Weng, X., Wands, J., Tong, S., 2009. Prevalence of basal core promoter and precore mutations in Chinese chronic hepatitis B patients and correlation with serum HBeAG titers. J Med Virol. 81, 807-14.

  • Qi, Z., Li, G., Hu, H., Yang, C., Zhang, X., Leng, Q., Xie, Y., Yu, D., Zhang, X., Gao, Y., Lan, K., Deng, Q., 2014. Recombinant covalently closed circular hepatitis B virus DNA induces prolonged viral persistence in immunocompetent mice. J Virol. 88, 8045-56.

  • Rodriguez-Frias, F., Jardi, R., Buti, M., Schaper, M., Hermosilla, E., Valdes, A., Allende, H., Martell, M., Esteban, R., Guardia, J., 2006. Hepatitis B virus genotypes and G1896A precore mutation in 486 Spanish patients with acute and chronic HBV infection. J Viral Hepat. 13, 343-350.

  • Samal, J., Kandpal, M., Vivekanandan, P., 2015. Hepatitis B "e" antigen-mediated inhibition of HBV replication fitness and transcription efficiency in vitro. Virology. 484, 234-240.

  • Sonneveld, M.J., Rijckborst, V., Zeuzem, S., Heathcote, E.J., Simon, K., Senturk, H., Pas, S.D., Hansen, B.E., Janssen, H.L., 2012. Presence of precore and core promoter mutants limits the probability of response to peginterferon in hepatitis B e antigen-positive chronic hepatitis B. Hepatology. 56, 67-75.

  • Sugiyama, M., Tanaka, Y., Kurbanov, F., Maruyama, I., Shimada, T., Takahashi, S., Shirai, T., Hino, K., Sakaida, I., Mizokami, M., 2009. Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes. Gastroenterology. 136, 652-662. e653.

  • Uchida, T.I.M., Hayes, C.N., Suehiro, Y., Teraoka, Y., Ohya, K., Aikata, H., Abe-Chayama, H., Ishida, Y., Tateno, C., Hara, Y., Hino, K., Okamoto, T., Matsuura, Y., Aizaki, H., Wake, K., Kohara, M., Liang, T.J., Oka, S., Chayama, K., 2023. HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice. Hepatology. 78, 929-942.

  • Wang, J., Huang, H., Liu, Y., Chen, R., Yan, Y., Shi, S., Xi, J., Zou, J., Yu, G., Feng, X., Lu, F., 2020. HBV Genome and Life Cycle. Adv Exp Med Biol. 1179, 17-37.

  • WHO., 2022. World Health Organization Global Hepatitis Report. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b.

  • Yang, D., Zou, J., Guan, G., Feng, X., Zhang, T., Li, G., Liu, H., Zheng, H., Xi, J., Yu, G., Dai, L., Lu, F., Chen, X., 2023. The A1762T/G1764A mutations enhance HBV replication by alternating viral transcriptome. J Med Virol. 95, e29129.

  • Yang, D., Zou, J., Wang, L., Chen, X., Lu, F., 2022. Letter to the editor:HBeAg expression suppressing/abolishing mutation elevated HBV DNA level in HBeAg-negative patients with chronic HBV infection. Hepatology. 76, E69-E70.

  • Yang, Y.H., Xie, Q., Wang, H., Zhou, H.J., Gui, H.L., Cai, W., Guo, S.M., Yu, H., Guo, Q., 2009. Viral factors influencing histological changes of HBeAg-negative chronic hepatitis B patients with persistently normal serum ALT levels. Zhonghua Gan Zang Bing Za Zhi. 17, 434-9.

  • Yan, H., Zhong, G., Xu, G., He, W., Jing, Z., Gao, Z., Huang, Y., Qi, Y., Peng, B., Wang, H., Fu, L., Song, M., Chen, P., Gao, W., Ren, B., Sun, Y., Cai, T., Feng, X., Sui, J., Li, W., 2012. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife. 1, e00049.

  • Yan, L.B., Tang, X.Q., Zhang, Q.B., Zhu, X., Bai, L., Du, L.Y., Chen, E.Q., Tang, H., 2018. Clinical features of hepatitis B e-antigen positive chronic hepatitis B patients co-existing precore and/or basal core promoter mutations. Future Virology. 13, 687-695.

  • Yim, S.Y., Um, S.H., Young Jung, J., Kim, T.H., Kim, J.D., Keum, B., Seo, Y.S., Yim, H.J., Jeen, Y.T., Lee, H.S., Chun, H.J., Kim, C.D., Ryu, H.S., 2015. Clinical significance of hepatitis B virus precore and core promoter variants in Korean patients with chronic hepatitis B. J Clin Gastroenterol. 49, 61-68.

  • Zhang, J., Xu, W.J., Wang, Q., Zhang, Y., Shi, M., 2009. Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen. Braz J Microbiol. 40, 965-971.

  • Zhao, B., Qiao, H., Zhao, Y., Gao, Z., Wang, W., Cui, Y., Li, J., Guo, Z., Chuai, X., Chiu, S., 2023. HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway. Virol Sin, 38, 680-689.