Citation: Hong-Qing Zhang, Zhe-Rui Zhang, Cheng-Lin Deng, Zhi-Ming Yuan, Bo Zhang. A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation .VIROLOGICA SINICA, 2024, 39(3) : 516-519.  http://dx.doi.org/10.1016/j.virs.2024.03.008

A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation

  • Corresponding author: Bo Zhang, zhangbo@wh.iov.cn
  • Received Date: 09 October 2023
    Accepted Date: 18 March 2024
    Available online: 24 March 2024
  • Highlights1. The recombinant VSV-EBOV is highly lethal to IFNα/β/γ R-/- mice.2. The infected mice exhibit hyperviremia and distinct splenohepatic lesions.3. Virus replicon particle vaccine can protect all IFNα/β/γ R-/- mice against VSV-EBOV lethal challenge.4. This surrogate model can be used for EBOV vaccine evaluation.

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    A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation

      Corresponding author: Bo Zhang, zhangbo@wh.iov.cn
    • a. Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China;
    • b. University of Chinese Academy of Sciences, Beijing, 100049, China;
    • c. Hubei Jiangxia Laboratory, Wuhan, 430200, China

    Abstract: Highlights1. The recombinant VSV-EBOV is highly lethal to IFNα/β/γ R-/- mice.2. The infected mice exhibit hyperviremia and distinct splenohepatic lesions.3. Virus replicon particle vaccine can protect all IFNα/β/γ R-/- mice against VSV-EBOV lethal challenge.4. This surrogate model can be used for EBOV vaccine evaluation.

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