Novel pegiviruses infecting wild birds and rodents

Wentao Zhu; Jing Yang; Shan Lu; Yuyuan Huang; Dong Jin; Ji Pu; Liyun Liu; Zhenjun Li; Mang Shi; Jianguo Xu

doi:10.1016/j.virs.2022.01.013

April 2022

Citation: Wentao Zhu, Jing Yang, Shan Lu, Yuyuan Huang, Dong Jin, Ji Pu, Liyun Liu, Zhenjun Li, Mang Shi, Jianguo Xu. Novel pegiviruses infecting wild birds and rodents .VIROLOGICA SINICA, 2022, 37(2) : 208-214. http://dx.doi.org/10.1016/j.virs.2022.01.013

Novel pegiviruses infecting wild birds and rodents

Wentao Zhu ^a ,
Jing Yang ^a,b,c ,
Shan Lu ^a,b,c ,
Yuyuan Huang ^a ,
Dong Jin ^a,b,c ,
Ji Pu ^a ,
Liyun Liu ^a,c ,
Zhenjun Li ^a ,
Mang Shi ^{d
,,} ,
Jianguo Xu ^{a,b,c,e
,,}

a State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China
b Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China
c Research Units of Discovery of Unknown Bacteria and Function, Chinese Academy of Medical Sciences, Beijing, 100730, China
d School of Medicine, Sun Yat-sen University, Shenzhen, 510006, China
e Research Institute of Public Heath, Nankai University, Tianjin, 300071, China

Corresponding author: Mang Shi, shim23@mail.sysu.edu.cn
Jianguo Xu, xujianguo@icdc.cn
Received Date: 30 August 2021
Accepted Date: 04 November 2021
Available online: 17 January 2022

Abstract

Pegivirus (family Flaviviridae) is a genus of small enveloped RNA viruses that mainly causes blood infections in various mammals including human. Herein, we carried out an extensive survey of pegiviruses from a wide range of wild animals mainly sampled in the Qinghai-Tibet Plateau of China. Three novel pegiviruses, namely Passer montanus pegivirus, Leucosticte brandti pegivirus and Montifringilla taczanowskii pegivirus, were identified from different wild birds, and one new rodent pegivirus, namely Phaiomys leucurus pegivirus, was identified from Blyth's vole. Interestingly, the pegiviruses of non-mammalian origin discovered in this study substantially broaden the host range of Pegivirus to avian species. Co-evolutionary analysis showed virus-host co-divergence over long evolutionary timescales, and indicated that pegiviruses largely followed a virus-host co-divergence relationship. Overall, this work extends the biodiversity of the Pegivirus genus to those infecting wild birds and hence revises the host range and evolutionary history of genus Pegivirus.
- Bird
- , Rat
- , Pegivirus
- , Evolution
- , Qinghai-Tibet Plateau

Electronic Supplementary Material

10.1016j.virs.2022.01.013-ESM.docx
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