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Citation: Xiaojie Zheng, Shengming Nie, Wen-Hai Feng. Regulation of antiviral immune response by African swine fever virus (ASFV) [J].VIROLOGICA SINICA, 2022, 37(2) : 157-167.  http://dx.doi.org/10.1016/j.virs.2022.03.006

Regulation of antiviral immune response by African swine fever virus (ASFV)

  • Corresponding author: Wen-Hai Feng, whfeng@cau.edu.cn
  • Received Date: 07 December 2021
    Accepted Date: 07 March 2022
    Available online: 09 March 2022
  • African swine fever (ASF) is a highly contagious and acute hemorrhagic viral disease with a high mortality approaching 100% in domestic pigs. ASF is an endemic in countries in sub-Saharan Africa. Now, it has been spreading to many countries, especially in Asia and Europe. Due to the fact that there is no commercial vaccine available for ASF to provide sustainable prevention, the disease has spread rapidly worldwide and caused great economic losses in swine industry. The knowledge gap of ASF virus (ASFV) pathogenesis and immune evasion is the main factor to limit the development of safe and effective ASF vaccines. Here, we will summarize the molecular mechanisms of how ASFV interferes with the host innate and adaptive immune responses. An in-depth understanding of ASFV immune evasion strategies will provide us with rational design of ASF vaccines.

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    Regulation of antiviral immune response by African swine fever virus (ASFV)

      Corresponding author: Wen-Hai Feng, whfeng@cau.edu.cn
    • a State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China
    • b Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China
    • c Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China

    Abstract: African swine fever (ASF) is a highly contagious and acute hemorrhagic viral disease with a high mortality approaching 100% in domestic pigs. ASF is an endemic in countries in sub-Saharan Africa. Now, it has been spreading to many countries, especially in Asia and Europe. Due to the fact that there is no commercial vaccine available for ASF to provide sustainable prevention, the disease has spread rapidly worldwide and caused great economic losses in swine industry. The knowledge gap of ASF virus (ASFV) pathogenesis and immune evasion is the main factor to limit the development of safe and effective ASF vaccines. Here, we will summarize the molecular mechanisms of how ASFV interferes with the host innate and adaptive immune responses. An in-depth understanding of ASFV immune evasion strategies will provide us with rational design of ASF vaccines.

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