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Citation: Shuaiyong Wang, Manzhu Wang, Lingxue Yu, Juan Wang, Jiecong Yan, Xinli Rong, Yanjun Zhou, Tongling Shan, Wu Tong, Guoxin Li, Hao Zheng, Guangzhi Tong, Hai Yu. Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus [J].VIROLOGICA SINICA, 2022, 37(4) : 627-630.  http://dx.doi.org/10.1016/j.virs.2022.04.009

Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus

  • Corresponding author: Hai Yu, haiyu_008@126.com
  • Received Date: 12 October 2021
    Accepted Date: 11 April 2022
    Available online: 02 May 2022
  • Highlights
    1. Identification of a reassortant EA H1N1 SIV (SD/18) which isolated from a pig farm in Shandong, north China.
    2. Phylogenetic analysis showed that SD/18 virus containing a complete internal gene cassette from pdm/09 virus.
    3. The results of pathogenicity in mice showed that the mortality rate of SD/18 virus in mice could reach 100%.
    4. The potential risk of EA lineage SIVs to humans is very high and we need to pay enough attention to the different reassortant EA H1N1 viruses.

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  • 10.1016j.virs.2022.04.009-ESM.docx
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    Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus

      Corresponding author: Hai Yu, haiyu_008@126.com
    • a Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;
    • b Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China

    Abstract: Highlights
    1. Identification of a reassortant EA H1N1 SIV (SD/18) which isolated from a pig farm in Shandong, north China.
    2. Phylogenetic analysis showed that SD/18 virus containing a complete internal gene cassette from pdm/09 virus.
    3. The results of pathogenicity in mice showed that the mortality rate of SD/18 virus in mice could reach 100%.
    4. The potential risk of EA lineage SIVs to humans is very high and we need to pay enough attention to the different reassortant EA H1N1 viruses.

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