For best viewing of the website please use Mozilla Firefox or Google Chrome.
Citation: Yingliang Duan, Zhenxing Yang, Pei Zhu, Lei Xiao, Zhanhong Li, Zhuoran Li, Le Li, Jianbo Zhu. A serologic investigation of epizootic hemorrhagic disease virus in China between 2014 and 2019 [J].VIROLOGICA SINICA, 2022, 37(4) : 513-520.  http://dx.doi.org/10.1016/j.virs.2022.06.005

A serologic investigation of epizootic hemorrhagic disease virus in China between 2014 and 2019

  • Corresponding author: Jianbo Zhu, zhujb70@126.com
  • Received Date: 10 December 2021
    Accepted Date: 13 June 2022
    Available online: 17 June 2022
  • Epizootic hemorrhagic disease virus (EHDV) is a member of the genus Orbivirus, family Sedoreoviridae. It was firstly recognized in 1955 to cause a highly fatal disease of wild white-tailed deer in America. So far, EHDV was detected and isolated in many wild or domestic ruminants, and widely distributed all over the world. Although the domestic cattle and sheep infected by EHDV were usually asymptomatic or subclinical, several outbreaks of epizootic hemorrhagic disease (EHD) in deer and cattle had been reported. Many EHDV strains were isolated and sequenced in last two decades in China, which promoted a general serologic investigation of EHDV in China. In this study, 18,122 sera were collected from asymptomatic or subclinical domestic ruminants (cattle, cow, yaks, sheep, goats, and deer) in 116 regions belonging to 15 provinces in China. All the sera were tested by EHDV C-ELISA, and the results were obtained by big data analysis. EHDV infections were detected in the 14 of 15 provinces, and only Tibet (average altitude ≥ 4000 m) which was the highest province in China was free of EHDV. The numbers of seropositive collections in both bovine and goat/sheep were in an inverse proportion to the latitude. However, the seropositive rates in bovine were ranged from 0% to 100%, while the seropositive rates in goat/sheep were no more than 50%. The results suggested that bovine was obviously more susceptive for EHDV infection than goat and sheep, therefore might be a major reservoir of EHDV in China. The prevalence of EHDV was consistent with the distribution of Culicoides which were known as the sole insect vectors of EHDV. In particular, the seropositive rates of EHDV were very high in the southern provinces, which required the enhanced surveillance in the future.

  • 加载中
  • 10.1016j.virs.2022.06.005-ESM.docx
    1. Allen, S.E., Rothenburger, J.L., Jardine, C.M., Ambagala, A., Hooper-McGrevy, K., Colucci, N., Furukawa-Stoffer, T., Vigil, S., Ruder, M., Nemeth, N.M., 2019. Epizootic hemorrhagic disease in white-tailed deer, Canada. Emerg. Infect. Dis. 25, 832–834.

    2. Anthony, S.J., Maan, N., Maan, S., Sutton, G., Attoui, H., Mertens, P.P., 2009a. Genetic and phylogenetic analysis of the core proteins VP1, VP3, VP4, VP6 and VP7 of epizootic haemorrhagic disease virus (EHDV). Virus Res. 145, 187–199.

    3. Anthony, S.J., Maan, S., Maan, N., Kgosana, L., Bachanek-Bankowska, K., Batten, C., Darpel, K.E., Sutton, G., Attoui, H., Mertens, P.P., 2009b. Genetic and phylogenetic analysis of the outer-coat proteins VP2 and VP5 of epizootic haemorrhagic disease virus (EHDV): comparison of genetic and serological data to characterise the EHDV serogroup. Virus Res. 145, 200–210.

    4. Aradaib, I.E., Mederos, R.A., Osburn, B.I., 2005. Evaluation of epizootic haemorrhagic disease virus infection in sentinel calves from the San Joaquin Valley of California.Vet. Res. Commun. 29, 447–451.

    5. Breard, E., Sailleau, C., Hamblin, C., Graham, S.D., Gourreau, J.M., Zientara, S., 2004.Outbreak of epizootic haemorrhagic disease on the island of Reunion. Vet. Rec. 155, 422–423.

    6. Campbell, C.H., St George, T.D., 1986. A preliminary report of a comparison of epizootic haemorrhagic disease viruses from Australia with others from north America, Japan and Nigeria. Aust. Vet. J. 63, 233.

    7. Casey, C.L., Rathbun, S.L., Stallknecht, D.E., Ruder, M.G., 2021. Spatial analysis of the 2017 outbreak of hemorrhagic disease and physiographic region in the eastern United States. Viruses 13, 550.

    8. Cetre-Sossah, C., Roger, M., Sailleau, C., Rieau, L., Zientara, S., Breard, E., Viarouge, C., Beral, M., Esnault, O., Cardinale, E., 2014. Epizootic haemorrhagic disease virus in Reunion Island: evidence for the circulation of a new serotype and associated risk factors. Vet. Microbiol. 170, 383–390.

    9. Cottingham, S.L., White, Z.S., Wisely, S.M., Campos-Krauer, J.M., 2021. A mortality-based description of EHDV and BTV prevalence in farmed white-tailed deer (Odocoileus virginianus) in Florida, USA. Viruses 13, 1443.

    10. Dommergues, L., Viarouge, C., Metras, R., Youssouffi, C., Sailleau, C., Zientara, S., Cardinale, E., Cetre-Sossah, C., 2019. Evidence of bluetongue and epizootic haemorrhagic disease circulation on the island of Mayotte. Acta Trop. 191, 24–28.

    11. Dunbar, M.R., Cunningham, M.W., Roof, J.C., 1998. Seroprevalence of selected disease agents from free-ranging black bears in Florida. J. Wildl. Dis. 34, 612–619.

    12. Golender, N., Bumbarov, V.Y., 2019. Detection of epizootic hemorrhagic disease virus serotype 1, Israel. Emerg. Infect. Dis. 25, 825–827.

    13. Gordon, S.J.G., Bolwell, C., Rogers, C.W., Musuka, G., Kelly, P., Guthrie, A., Mellor, P.S., Hamblin, C., 2017. A serosurvey of bluetongue and epizootic haemorrhagic disease in a convenience sample of sheep and cattle herds in Zimbabwe. Onderstepoort J. Vet.Res. 84, e1–e5.

    14. Greene, C.S., Tan, J., Ung, M., Moore, J.H., Cheng, C., 2014. Big data bioinformatics.J. Cell. Physiol. 229, 1896–1900.

    15. Hirashima, Y., Kato, T., Yamakawa, M., Shirafuji, H., Okano, R., Yanase, T., 2015.Reemergence of Ibaraki disease in southern Japan in 2013. J. Vet. Med. Sci. 77, 1253–1259.

    16. Kamomae, Y., Kamomae, M., Ohta, Y., Nabe, M., Kagawa, Y., Ogura, Y., Kato, T., Tanaka, S., Yanase, T., Shirafuji, H., 2018. Epizootic hemorrhagic disease virus serotype 6 infection in cattle, Japan, 2015. Emerg. Infect. Dis. 24, 902–905.

    17. Kato, T., Shirafuji, H., Tanaka, S., Sato, M., Yamakawa, M., Tsuda, T., Yanase, T., 2016.Bovine arboviruses in Culicoides biting midges and sentinel cattle in southern Japan from 2003 to 2013. Transbound. Emerg. Dis. 63, e160–e172.

    18. Kedmi, M., Galon, N., Herziger, Y., Yadin, H., Bombarov, V., Batten, C., Shpigel, N.Y., Klement, E., 2011. Comparison of the epidemiology of epizootic haemorrhagic disease and bluetongue viruses in dairy cattle in Israel. Vet. J. 190, 77–83.

    19. Li, M., Zheng, Y., Zhao, G., Fu, S., Wang, D., Wang, Z., Liang, G., 2014. Tibet Orbivirus, a novel Orbivirus species isolated from Anopheles maculatus mosquitoes in Tibet, China.PLoS One 9, e88738.

    20. Li, X.C., 1990. The first research of diagnostic method for deer epizootic hemorrhagic disease. Anim. Health Insp. 9, 3–6 (in Chinese).

    21. Lortie, C.J., Braun, J., Filazzola, A., Miguel, F., 2020. A checklist for choosing between R packages in ecology and evolution. Ecol. Evol. 10, 1098–1105.

    22. Ma, J.G., Zhang, X.X., Zheng, W.B., Xu, Y.T., Zhu, X.Q., Hu, G.X., Zhou, D.H., 2017.Seroprevalence and risk factors of bluetongue virus infection in Tibetan sheep and yaks in Tibetan Plateau. China. Biomed. Res. Int. 5139703.

    23. Maan, N.S., Maan, S., Potgieter, A.C., Wright, I.M., Belaganahalli, M., Mertens, P.P.C., 2017. Development of real-time RT-PCR assays for detection and typing of epizootic haemorrhagic disease virus. Transbound Emerg Dis 64, 1120–1132.

    24. Maan, N.S., Maan, S., Nomikou, K., Johnson, D.J., El Harrak, M., Madani, H., Yadin, H., Incoglu, S., Yesilbag, K., Allison, A.B., Stallknecht, D.E., Batten, C., Anthony, S.J., Mertens, P.P., 2010. RT-PCR assays for seven serotypes of epizootic haemorrhagic disease virus & their use to type strains from the Mediterranean region and north America. PLoS One 5, e12782.

    25. Maclachlan, N.J., Zientara, S., Savini, G., Daniels, P.W., 2015. Epizootic haemorrhagic disease. Rev. Sci. Tech. 34, 341–351.

    26. Mahmoud, A., Danzetta, M.L., di Sabatino, D., Spedicato, M., Alkhatal, Z., Dayhum, A., Tolari, F., Forzan, M., Mazzei, M., Savini, G., 2021. First seroprevalence investigation of epizootic haemorrhagic disease virus in Libya. Open Vet. J. 11, 301–308.

    27. McGill, R., Tukey, J.W., Larsen, W.A., 1978. Variations of box plots. Am. Statistician 32, 12–16.

    28. Mejri, S., Dhaou, S.B., Jemli, M., Breard, E., Sailleau, C., Sghaier, S., Zouari, M., Lorusso, A., Savini, G., Zientara, S., Hammami, S., 2018. Epizootic haemorrhagic disease virus circulation in Tunisia. Vet. Ital. 54, 87–90.

    29. Mellor, P.S., Boorman, J., Baylis, M., 2000. Culicoides biting midges: their role as arbovirus vectors. Annu. Rev. Entomol. 45, 307–340.

    30. Miller, M., Buss, P., Joubert, J., Maseko, N., Hofmeyr, M., Gerdes, T., 2011. Serosurvey for selected viral agents in white rhinoceros (Ceratotherium simum) in Kruger national park, 2007. J. Zoo Wildl. Med. 42, 29–32.

    31. Ohashi, S., Yoshida, K., Watanabe, Y., Tsuda, T., 1999. Identification and PCR-restriction fragment length polymorphism analysis of a variant of the Ibaraki virus from naturally infected cattle and aborted fetuses in Japan. J. Clin. Microbiol. 37, 3800–3803.

    32. OIE, 2021. Epizootic haemorrhagic disease (infection with epizootic hemorrhagic disease virus. https://www.oie.int/fileadmin/Home/eng/Health_standards/tahm/3.01.0 7_EHD.pdf. (Accessed 25 February 2022).

    33. Omori, T., Inaba, Y., Morimoto, T., Tanaka, Y., Ishitani, R., 1969. Ibaraki virus, an agent of epizootic disease of cattle resembling bluetongue. I. Epidemiologic, clinical and pathologic observations and experimental transmission to calves. Jpn. J. Microbiol. 13, 139–157.

    34. Qi, Y., Wang, F., Chang, J., Zhang, Y., Zhu, J., Li, H., Yu, L., 2019. Identification and complete-genome phylogenetic analysis of an epizootic hemorrhagic disease virus serotype 7 strain isolated in China. Arch. Virol. 164, 3121–3126.

    35. Raabis, S.M., Byers, S.R., Han, S., Callan, R.J., 2014. Epizootic hemorrhagic disease in a yak. Can. Vet. J. 55, 369–372.

    36. Roy, P., 2007. Orbiviruses. In: Knipe, D.M., Howley, P.M. (Eds.), Fields Virology, fifth ed., vol. 2. Wolters Kluwer/Lippincott Williams & Wilkins Health, Philadelphia, PA, pp. 2541–2568.

    37. Sailleau, C., Zanella, G., Breard, E., Viarouge, C., Desprat, A., Vitour, D., Adam, M., Lasne, L., Martrenchar, A., Bakkali-Kassimi, L., Costes, L., Zientara, S., 2012. Cocirculation of bluetongue and epizootic haemorrhagic disease viruses in cattle in Reunion Island. Vet. Microbiol. 155, 191–197.

    38. Savini, G., Afonso, A., Mellor, P., Aradaib, I., Yadin, H., Sanaa, M., Wilson, W., Monaco, F., Domingo, M., 2011. Epizootic heamorragic disease. Res. Vet. Sci. 91, 1–17.

    39. Shirafuji, H., Kato, T., Yamakawa, M., Tanaka, T., Minemori, Y., Yanase, T., 2017.Characterization of genome segments 2, 3 and 6 of epizootic hemorrhagic disease virus strains isolated in Japan in 1985-2013: identification of their serotypes and geographical genetic types. Infect. Genet. Evol. 53, 38–46.

    40. Shope, R.E., Macnamara, L.G., Mangold, R., 1960. A virus-induced epizootic hemorrhagic disease of the Virginia white-tailed deer (Odocoileus virginianus). J. Exp. Med. 111, 155–170.

    41. Temizel, E.M., Yesilbag, K., Batten, C., Senturk, S., Maan, N.S., Mertens, P.P.C., Batmaz, H., 2009. Epizootic hemorrhagic disease in cattle, western Turkey. Emerg.Infect. Dis. 15, 317–319.

    42. Toye, P.G., Batten, C.A., Kiara, H., Henstock, M.R., Edwards, L., Thumbi, S., Poole, E.J., Handel, I.G., Bronsvoort, B.M., Hanotte, O., Coetzer, J.A., Woolhouse, M.E., Oura, C.A., 2013. Bluetongue and epizootic haemorrhagic disease virus in local breeds of cattle in Kenya. Res. Vet. Sci. 94, 769–773.

    43. Verdezoto, J., Breard, E., Viarouge, C., Quenault, H., Lucas, P., Sailleau, C., Zientara, S., Augot, D., Zapata, S., 2018. Novel. Serotype of bluetongue virus in south America and first report of epizootic haemorrhagic disease virus in Ecuador. Transbound Emerg Dis 65, 244–247.

    44. Wilson, A., Mellor, P., 2008. Bluetongue in europe: vectors, epidemiology and climate change. Parasitol. Res. 103 (Suppl. 1), S69–S77.

    45. Xue, D.M., Zhang, G.X., Liu, A.D., Zhang, Q.Y., Li, D.C., Guo, Y.Z., Huang, D.J., Yang, B.S., 1987. Suspicious Ibaraki disease in cattle. J. Anim. Sci. Vet. Med. 6, 43–44 (in Chinese).

    46. Yamamoto, K., Hiromatsu, R., Kaida, M., Kato, T., Yanase, T., Shirafuji, H., 2021. Isolation of epizootic hemorrhagic disease virus serotype 7 from cattle showing fever in Japan in 2016 and improvement of a reverse transcription-polymerase chain reaction assay to detect epizootic hemorrhagic disease virus. J. Vet. Med. Sci. 83, 1378–1388.

    47. Yanase, T., Murota, K., Hayama, Y., 2020. Endemic and emerging arboviruses in domestic ruminants in east Asia. Front. Vet. Sci. 7, 168.

    48. Yang, H., Li, Z., Wang, J., Yang, Z., Liao, D., Zhu, J., Li, H., 2020. Novel. Serotype of epizootic hemorrhagic disease virus, China. Emerg. Infect. Dis. 26, 3081–3083.

    49. Yang, Z., Lyu, M., Zhu, P., Yang, H., Xiao, L., Liao, D., Xie, J., Zhu, J., Li, H., 2019. Seroantibody investigation of epizootic haemorrhagic disease of cattle and sheep in China. Chin. J. Prev. Vet. Med. 41, 29–34 (in Chinese).

    50. Zhang, Y.X., Lin, J., Cao, Y.Y., Zhu, J.B., Du, Y.C., Yang, Z.X., Yao, J., Li, H.C., Wu, J.M., 2016. Investigation of the serotypes of epizootic hemorrhagic disease virus and analysis of their distribution in Guangxi. Shanghai J. Anim. Husb. Vet. Med. 61, 19–21 (in Chinese).

    51. Zhu, J., Yang, Z., Xiao, L., Gao, L., Miao, H., He, Y., Meng, J., Yang, H., Li, H., 2018. Establishment of a rapid competitive ELISA for detecting antibodies against epizootic haemorrhagic disease virus. Acta Vet. Zootech. Sin. 49, 1440–1450 (in Chinese).

  • 加载中

Article Metrics

Article views(296) PDF downloads(9) Cited by()

Related
Proportional views
    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    A serologic investigation of epizootic hemorrhagic disease virus in China between 2014 and 2019

      Corresponding author: Jianbo Zhu, zhujb70@126.com
    • Yunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Yunnan Animal Science and Veterinary Institute, Kunming, 650000, China

    Abstract: Epizootic hemorrhagic disease virus (EHDV) is a member of the genus Orbivirus, family Sedoreoviridae. It was firstly recognized in 1955 to cause a highly fatal disease of wild white-tailed deer in America. So far, EHDV was detected and isolated in many wild or domestic ruminants, and widely distributed all over the world. Although the domestic cattle and sheep infected by EHDV were usually asymptomatic or subclinical, several outbreaks of epizootic hemorrhagic disease (EHD) in deer and cattle had been reported. Many EHDV strains were isolated and sequenced in last two decades in China, which promoted a general serologic investigation of EHDV in China. In this study, 18,122 sera were collected from asymptomatic or subclinical domestic ruminants (cattle, cow, yaks, sheep, goats, and deer) in 116 regions belonging to 15 provinces in China. All the sera were tested by EHDV C-ELISA, and the results were obtained by big data analysis. EHDV infections were detected in the 14 of 15 provinces, and only Tibet (average altitude ≥ 4000 m) which was the highest province in China was free of EHDV. The numbers of seropositive collections in both bovine and goat/sheep were in an inverse proportion to the latitude. However, the seropositive rates in bovine were ranged from 0% to 100%, while the seropositive rates in goat/sheep were no more than 50%. The results suggested that bovine was obviously more susceptive for EHDV infection than goat and sheep, therefore might be a major reservoir of EHDV in China. The prevalence of EHDV was consistent with the distribution of Culicoides which were known as the sole insect vectors of EHDV. In particular, the seropositive rates of EHDV were very high in the southern provinces, which required the enhanced surveillance in the future.

    Reference (51) Relative (20)

    目录

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return