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Citation: Moiz Ahmed Khan, Kehkashan Imtiaz, Humaira Shafaq, Joveria Farooqi, Mohammad Hassan, Afia Zafar, Maureen T. Long, Kelli L. Barr, Erum Khan. Screening for arboviruses in healthy blood donors: Experience from Karachi, Pakistan [J].VIROLOGICA SINICA, 2022, 37(5) : 774-777.  http://dx.doi.org/10.1016/j.virs.2022.07.008

Screening for arboviruses in healthy blood donors: Experience from Karachi, Pakistan

  • Corresponding author: Erum Khan, erum.khan@aku.edu
  • Received Date: 15 December 2021
    Accepted Date: 13 July 2022
    Available online: 19 July 2022
  • Highlights:
    1 Potential transfusion-related transmission of DENV, WNV and JEV was investigated in healthy blood donors from the blood bank of Aga Khan University during July to December 2018.
    2 ELISA for DENV, WNV and JEV IgM antibodies and RT-PCR for viral RNA detection were performed.
    3 Of the 360 blood donors screened, IgM antibodies for DENV and WNV were positive in 3.9% and JEV in 0.28% respectively while none of the blood donors tested positive for RT-PCR.
    4 Majority of the seropositive donors were between 19 to 30 years of age and residents of urban areas, mainly from Karachi City.
    5 DENV and WNV seropositivity were significantly associated with residence in Malir District of Karachi.

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    10. Khan, E., Barr, K.L., Farooqi, J.Q., Prakoso, D., Abbas, A., Khan, Z.Y., Ashi, S., Imtiaz, K., Aziz, Z., Malik, F., Lednicky, J.A., Long, M.T., 2018. Human West Nile virus disease outbreak in Pakistan, 2015-2016. Front. Public Health 6, 20.

    11. Khan, E., Prakoso, D., Imtiaz, K., Malik, F., Farooqi, J.Q., Long, M.T., Barr, K.L., 2020. The clinical features of co-circulating dengue viruses and the absence of dengue hemorrhagic fever in Pakistan. Front. Public Health 8, 287.

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    Screening for arboviruses in healthy blood donors: Experience from Karachi, Pakistan

      Corresponding author: Erum Khan, erum.khan@aku.edu
    • a Clinical Microbiology Laboratory, Department of Pathology & Lab Medicine, Aga Khan University, Karachi 74800, Pakistan;
    • b Blood Bank, Haematology & Transfusion Medicine, Department of Pathology & Lab Medicine, Aga Khan University, Karachi 74800, Pakistan;
    • c Comparative Diagnostic and Population Medicine, University of Florida, Gainesville FL32611, USA;
    • d Center for Global Health and Infectious Disease Research, University of South Florida, Tampa FL33620, USA

    Abstract: Highlights:
    1 Potential transfusion-related transmission of DENV, WNV and JEV was investigated in healthy blood donors from the blood bank of Aga Khan University during July to December 2018.
    2 ELISA for DENV, WNV and JEV IgM antibodies and RT-PCR for viral RNA detection were performed.
    3 Of the 360 blood donors screened, IgM antibodies for DENV and WNV were positive in 3.9% and JEV in 0.28% respectively while none of the blood donors tested positive for RT-PCR.
    4 Majority of the seropositive donors were between 19 to 30 years of age and residents of urban areas, mainly from Karachi City.
    5 DENV and WNV seropositivity were significantly associated with residence in Malir District of Karachi.

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