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Citation: Jing-Yu Wang, Tian-Ning Li, Chun-Lei Zhou, Jie Zhao, Meng Wang, Yuan Wang, Yan Jiang, He-Nan Dong, Qian-Ru Qi, Hong Mu. Clinical and immunological features of convalescent pediatric patients infected with the SARS-CoV-2 Omicron variant in Tianjin, China [J].VIROLOGICA SINICA, 2022, 37(6) : 850-859.  http://dx.doi.org/10.1016/j.virs.2022.10.009

Clinical and immunological features of convalescent pediatric patients infected with the SARS-CoV-2 Omicron variant in Tianjin, China

  • Corresponding author: Hong Mu, tjmuhong@163.com
  • Received Date: 24 April 2022
    Accepted Date: 27 October 2022
    Available online: 31 October 2022
  • COVID-19 has spread surprisingly fast worldwide, and new variants continue to emerge. Recently, the World Health Organization acknowledged a new mutant strain “Omicron”, with children were accounting for a growing share of COVID-19 cases compared with other mutant strains. However, the clinical and immunological characteristics of convalescent pediatric patients after Omicron infection were lacking. In this study, we comparatively analyzed the clinical data from pediatric patients with adult patients or healthy children and the effects of SARSCoV-2 vaccine on the clinical and immune characteristics in convalescent pediatric patients. Our results indicated that convalescent pediatric patients had unique clinical and immune characteristics different from those of adult patients or healthy children, and SARS-CoV-2 vaccination significantly affected on the clinical and immune characteristics and the prevention of nucleic acid re-detectable positive (RP) in convalescent patients. Our study further deepens the understanding of the impact of Omicron on the long-term health of pediatric patients and provides a valuable reference for the prevention and treatment of children infected with Omicron.

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  • 10.1016j.virs.2022.10.009-ESM.docx
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    Clinical and immunological features of convalescent pediatric patients infected with the SARS-CoV-2 Omicron variant in Tianjin, China

      Corresponding author: Hong Mu, tjmuhong@163.com
    • a Department of Clinical Lab, Tianjin First Central Hospital, Tianjin, 300192, China;
    • b The First Central Clinical College, Tianjin Medical University, Tianjin, 300192, China;
    • c Department of Clinical Lab, Tianjin Children's Hospital, Tianjin, 300074, China

    Abstract: COVID-19 has spread surprisingly fast worldwide, and new variants continue to emerge. Recently, the World Health Organization acknowledged a new mutant strain “Omicron”, with children were accounting for a growing share of COVID-19 cases compared with other mutant strains. However, the clinical and immunological characteristics of convalescent pediatric patients after Omicron infection were lacking. In this study, we comparatively analyzed the clinical data from pediatric patients with adult patients or healthy children and the effects of SARSCoV-2 vaccine on the clinical and immune characteristics in convalescent pediatric patients. Our results indicated that convalescent pediatric patients had unique clinical and immune characteristics different from those of adult patients or healthy children, and SARS-CoV-2 vaccination significantly affected on the clinical and immune characteristics and the prevention of nucleic acid re-detectable positive (RP) in convalescent patients. Our study further deepens the understanding of the impact of Omicron on the long-term health of pediatric patients and provides a valuable reference for the prevention and treatment of children infected with Omicron.

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