MAN Yan-Gao, CHEN Min-Hui, HU Li-Ping, LEI Sen-Lin and CHEN Hong-Bin. THE MORPHOLOGICAL MANIFASTATIONS OF THE CERVICAL TISSUE AND EXFOLIATED CELLS OF MICE INFECTED INTRAVAGINALLY WITH LIVING AND INACTIVED TYPE 2 HERPESVIRUSES.[J]. Virologica Sinica, 1987, 2(2).
Citation:
MAN Yan-Gao, CHEN Min-Hui, HU Li-Ping, LEI Sen-Lin, CHEN Hong-Bin.
THE MORPHOLOGICAL MANIFASTATIONS OF THE CERVICAL TISSUE AND EXFOLIATED CELLS OF MICE INFECTED INTRAVAGINALLY WITH LIVING AND INACTIVED TYPE 2 HERPESVIRUSES. .VIROLOGICA SINICA, 1987, 2(2)
: 37.
小鼠宫颈活及灭活HSV-2感染时局部组织与脱落细胞的形态学特征
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1.
湖北医学院病毒研究所细胞生物室
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湖北医学院病毒研究所细胞生物室 武汉
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摘要
本实验将活及灭活单纯疱疹Ⅱ型病毒(HSV-2)接种于小鼠宫颈处,然后连续取宫颈组织及脱落细胞,行巴氏、H-E及免疫荧光染色,光镜观察,旨在为HSV-2感染的防治研究提供病理组织学诊断依据及更为理想的动物模型。本实验发现,活病毒组可出现以下病变;1.细胞肿胀,体积增大;2.多核巨细胞形成;3.核内出现嗜酸性包涵体;4.核仁、染色质呈粗颗粒状或块状,甚至融解;5.细胞固缩、融解或气球样变;6.宫颈、阴道上皮出现疱疹;7.病变细胞内出现HSV-2的特异性抗原。灭活病毒组的变化与上述基本类似,但有以下区别;1.病变出现晚,但持续时间长;2.白细胞浸润现象极明显;3.细胞坏死现象少见,多核细胞甚多,并可见一些细胞聚集成花瓣或豆芽状,细胞之间有丝状或带状胞质桥相连。对照组无上述改变。对本试验的意义及灭活病毒引起细胞病变等问题进行了讨论。
THE MORPHOLOGICAL MANIFASTATIONS OF THE CERVICAL TISSUE AND EXFOLIATED CELLS OF MICE INFECTED INTRAVAGINALLY WITH LIVING AND INACTIVED TYPE 2 HERPESVIRUSES.
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Abstract
The living and inactived by U.V.type 2 herpes simplex viruses wer inoculated into the cervix of mice.The sequential cytological manifastations of vagina and cervix can be summarized as follows.1. The first visible light-microscopic change is the hypertrophy of the cytoplasm and nucleus of infected cells,this increase the cell in size.2. Many cells were fused to form a multinuclear cell3. The single. coarsely granular,acidophilic intranuclear inclusion was found in the infected cells4. Nucleoli and nuclear c...
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