当期论文

Influenza A virus (IAV) possesses a broad host range and undergoes rapid genomic variation, leading to the continuous emergence of novel viruses with significant antigenic variations and cross-species transmission potential. Understanding the evolutionary patterns and underlying mechanisms of all IAVs is crucial for effective prevention and control. However, current genetic clustering methods, such as phylogenetic-based and genetic distance-based approaches, lack phylogenetic information, which hinders the identification of complex events such as reassortments. In this issue, Ding et al. developed a novel genotype identification method, named FluTyping, to enhance the investigation of IAV genotype-based evolution. Based on both genetic distance and phylogenetic relationships, FluTyping established a comprehensive set of classification for all IAVs using whole genome sequences, offering a macro perspective of IAVs' genetic diversity patterns and their restriction factors. The cover image depicts IAVs with multi-genotypes co-circulation patterns show region-specific dominant genotypes, and the restriction of IAV transmission within specific regions contributes to the prevalence of certain genotypes (Kindly designed and provided by Dr. Xiao Ding, Prof. Aiping Wu and Prof. Taijiao Jiang). See page 525–536 for details.