QIU Su-Ying, CAO Zong-Li, DONG Jie-De, CHEN Chen-Hua, ZENG Li, SONG Yuan-Di and XU Xiu-Ping. Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus[J]. Virologica Sinica, 1988, 3(1).
Citation:
QIU Su-Ying, CAO Zong-Li, DONG Jie-De, CHEN Chen-Hua, ZENG Li, SONG Yuan-Di, XU Xiu-Ping.
Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus .VIROLOGICA SINICA, 1988, 3(1)
: 27.
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摘要
本文对我室用单纯疱疹病毒Ⅱ型转化的人胚肺细胞进行了某些生物学特性的研究。结果证明三系转化细胞均显示染色体数目增加,核型大多数为亚三倍体;对血清要求降低,能在1%血清培养液中生长,生长速度快;能被刀豆A(12.5—100μg/ml)凝集;软琼脂中能形成集落;能在裸鼠体内成瘤(两个系成瘤率100%,一个系成瘤率66%)。以上特性说明转化细胞具有恶性细胞的特徵。
Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus
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Abstract
The biological properties of three cell lines transformed by HSV-2 were investigated. The results indicate that the transformed cell lines possess the following characteristies:(1) chromosomal abnormalities; (2) reduce of requirement for serum factor; (3) rapid growth; (4) colony formation in soft agar; (5) increase of agglutination by Con Aand(6) induction of malignant tumor in nude mice These strongly suggest that the transformed cells are neoplastic.
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Proportional views
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