Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus

QIU Su-Ying; CAO Zong-Li; DONG Jie-De; CHEN Chen-Hua; ZENG Li; SONG Yuan-Di; XU Xiu-Ping

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February 1988

QIU Su-Ying, CAO Zong-Li, DONG Jie-De, CHEN Chen-Hua, ZENG Li, SONG Yuan-Di and XU Xiu-Ping. Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus[J]. Virologica Sinica, 1988, 3(1).

Citation: QIU Su-Ying, CAO Zong-Li, DONG Jie-De, CHEN Chen-Hua, ZENG Li, SONG Yuan-Di, XU Xiu-Ping. Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus .VIROLOGICA SINICA, 1988, 3(1) : 27.

单纯疱疹病毒转化的细胞系生物学特性的研究

1.
山东医科大学微生物学教研室
2.
山东医科大学微生物学教研室济南

摘要

本文对我室用单纯疱疹病毒Ⅱ型转化的人胚肺细胞进行了某些生物学特性的研究。结果证明三系转化细胞均显示染色体数目增加,核型大多数为亚三倍体;对血清要求降低,能在1％血清培养液中生长,生长速度快;能被刀豆A(12.5—100μg/ml)凝集;软琼脂中能形成集落;能在裸鼠体内成瘤(两个系成瘤率100％,一个系成瘤率66％)。以上特性说明转化细胞具有恶性细胞的特徵。

Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus

1.
Department of Microbiology
2.
Shandong Medical University

Abstract

The biological properties of three cell lines transformed by HSV-2 were investigated. The results indicate that the transformed cell lines possess the following characteristies:(1) chromosomal abnormalities; (2) reduce of requirement for serum factor; (3) rapid growth; (4) colony formation in soft agar; (5) increase of agglutination by Con Aand(6) induction of malignant tumor in nude mice These strongly suggest that the transformed cells are neoplastic.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus

1. Department of Microbiology
2. Shandong Medical University

Abstract: The biological properties of three cell lines transformed by HSV-2 were investigated. The results indicate that the transformed cell lines possess the following characteristies:(1) chromosomal abnormalities; (2) reduce of requirement for serum factor; (3) rapid growth; (4) colony formation in soft agar; (5) increase of agglutination by Con Aand(6) induction of malignant tumor in nude mice These strongly suggest that the transformed cells are neoplastic.