Analysis of AIDS KS Biopsy and Peripheral Blood Lymphocyte Specimens for Human Cytomegalovirus Transforming DNA Sequences

Leonard J.Rosenthal; Stephen M.Peters; Abdur Razzaque

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August 1988

Leonard J.Rosenthal, Stephen M.Peters and Abdur Razzaque. Analysis of AIDS KS Biopsy and Peripheral Blood Lymphocyte Specimens for Human Cytomegalovirus Transforming DNA Sequences[J]. Virologica Sinica, 1988, 3(4).

Citation: Leonard J.Rosenthal, Stephen M.Peters, Abdur Razzaque. Analysis of AIDS KS Biopsy and Peripheral Blood Lymphocyte Specimens for Human Cytomegalovirus Transforming DNA Sequences .VIROLOGICA SINICA, 1988, 3(4) : 317.

分析艾滋病卡波济氏肉瘤活检组织中及外周血淋巴细胞样品中人巨噬细胞病毒转化的DNA序列(英文)

1.
Department of Microbiology and Vincent T. Lombardi Cancer Center
2.
Department of Pediatrics and Immunology Center Georgetown University Medical Center Washington D. C. 20007 U.S.A

摘要

美国华盛顿乔治城大学医学中心微生物系LeonardJ.Rosenthal教授,长期从事CMV,HSV,VSV的感染,复制,转化及其DNA序列等分子病毒学的研究。近来他开展AIDS的研究工作,特别是研究CMV,HSV对AIDS的发病关系,在美国颇有声誉。本文是作者通过人的卡波济氏肉瘤(KS)组织活俭及外周血淋巴细胞(PBL)的核酸分子杂交,以研究HCMV在AIDS发病过程中的作用。为了更好地保持作者原意,促进国际学术交流,本文以原文发表。

Analysis of AIDS KS Biopsy and Peripheral Blood Lymphocyte Specimens for Human Cytomegalovirus Transforming DNA Sequences

1.
Department of Microbiology and Vincent T. Lombardi Cancer Center
2.
Department of Pediatrics and Immunology Center Georgetown University Medical Center Washington D. C. 20007 U.S.A

Abstract

Investigation into the role of human eytomegalovirus (HCMV) in the development of AIDS/KS was carried out by nucleic acid hybridization analyses of both human KS biopsy and peripheral blood lymphocyte (PBL) specimens for the presence of HCMV transforming mtrⅡ and mtrⅢ DNA sequences. In one set of experiments, Southern blot analysis revealed the presence of mtrⅡ sequences in only 2 out of 6 KS biopsies, while mtrⅢ sequences were not detected in any of the biopsies. The general absence of both mtrⅡ and Ⅲ tran...

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

Analysis of AIDS KS Biopsy and Peripheral Blood Lymphocyte Specimens for Human Cytomegalovirus Transforming DNA Sequences

1. Department of Microbiology and Vincent T. Lombardi Cancer Center
2. Department of Pediatrics and Immunology Center Georgetown University Medical Center Washington D. C. 20007 U.S.A

Abstract: Investigation into the role of human eytomegalovirus (HCMV) in the development of AIDS/KS was carried out by nucleic acid hybridization analyses of both human KS biopsy and peripheral blood lymphocyte (PBL) specimens for the presence of HCMV transforming mtrⅡ and mtrⅢ DNA sequences. In one set of experiments, Southern blot analysis revealed the presence of mtrⅡ sequences in only 2 out of 6 KS biopsies, while mtrⅢ sequences were not detected in any of the biopsies. The general absence of both mtrⅡ and Ⅲ tran...