Investigation on Anti-idiotypes Directed against Anti-HBs in HBV Infection

XU Xiu-Ping; Steve A.Jenison

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June 1990

XU Xiu-Ping and Steve A.Jenison. Investigation on Anti-idiotypes Directed against Anti-HBs in HBV Infection[J]. Virologica Sinica, 1990, 5(3).

Citation: XU Xiu-Ping, Steve A.Jenison. Investigation on Anti-idiotypes Directed against Anti-HBs in HBV Infection .VIROLOGICA SINICA, 1990, 5(3) : 245.

人乳头瘤病毒16型E_7开放读码框编码免疫反应表位的定位

1.
山东医科大学微生物教研室
2.
西亚图Fred 济南
3.
Hutchinson肿瘤研究中心
4.
美国 98104

摘要

1.75％聚乙二醇(MW6000)沉淀血清免疫复合物后,采用ELISA法检测上清中抗独特型抗体〔抗-(抗-HBs)〕。56例急性HBV感染患者血清IgM抗-(抗-HBs),第一周检出率最高(60.00％),1个月后大部分阴性,IgG抗-(抗-HBs)维持时间略长。IgM抗-(抗-HBs)较HBsAg/IgM和IgM抗-HBc消失早,将有利于急性HBV感染的诊断。27例CAH和29例CPH,IgM和IgG抗-(抗-HBs)阳性率约为38～52％,两型间无显著差异(p>0.5)。3例无症状HBsAg携带者和12例HBsAg血清疫苗接受者血清,抗-(抗-HBs)阴性。115例HBV感染者中,IgM抗-(抗-HBs)阳性者HBsAg阳性率(93.62)显著高于IgM抗-(抗-HBs)阴性者(52.31％),p<0.005;反之,HBsAg阳性血清IgM抗-(抗-HBs)阳性率(55.5S％)显著高于HBsAg阴性血清(9.68％),p<0.005;IgM抗-(抗-HBs)阳性和阴性血清的HBVDNA阳性率有显著差异(p<0.025),IgG反应到类似的结果。以上资料表明,抗-(抗-HBs)提示了一些HBV感染患者体内...
- HBV感染
- , “a”特异性共同独特型
- , 抗独特型抗体[抗-（抗-HBs）]
- , ELISA

Investigation on Anti-idiotypes Directed against Anti-HBs in HBV Infection

1.
Hangzhou Sixth People s Hosptal
2.
Hongzhou 310014

Abstract

Anti-idiotypes directed against anti-HBs in the supernatant were detected by enzyme-linked immunosorbent assay (ELISA) after precipitation of immune complexes from sera with polyethylene glycol 6000(PEG). 115 patients with HBV infection were observed. IgM and IgG anti-(anti-HBs) activities existed in acute hepatitis, CAH and CPH. The positive rate of anti(anti-HBs) in the first week after onset was the highest in acute hepatitis(60.%). After one month Later it fell markedly Therefore detecting anti(anti-HBs...
- HBV infection Common Id with“a”specifieity Anti （anti-HBsId） ELISA

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Investigation on Anti-idiotypes Directed against Anti-HBs in HBV Infection

1. Hangzhou Sixth People s Hosptal
2. Hongzhou 310014

Abstract: Anti-idiotypes directed against anti-HBs in the supernatant were detected by enzyme-linked immunosorbent assay (ELISA) after precipitation of immune complexes from sera with polyethylene glycol 6000(PEG). 115 patients with HBV infection were observed. IgM and IgG anti-(anti-HBs) activities existed in acute hepatitis, CAH and CPH. The positive rate of anti(anti-HBs) in the first week after onset was the highest in acute hepatitis(60.%). After one month Later it fell markedly Therefore detecting anti(anti-HBs...