Detection of the HCV C(33c) Antigen and HBxAg in Liver Cirrhositic Tissues by Immunohistochemical Techniques

WANG Chun-Jie; WANG Wen-Liang; WANG Bo

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April 1995

WANG Chun-Jie, WANG Wen-Liang and WANG Bo. Detection of the HCV C(33c) Antigen and HBxAg in Liver Cirrhositic Tissues by Immunohistochemical Techniques[J]. Virologica Sinica, 1995, 10(2).

Citation: WANG Chun-Jie, WANG Wen-Liang, WANG Bo. Detection of the HCV C(33c) Antigen and HBxAg in Liver Cirrhositic Tissues by Immunohistochemical Techniques .VIROLOGICA SINICA, 1995, 10(2) : 135.

肝硬变中丙型肝炎病毒C（33）c抗原及HBxAg的分布及意义

1.
第四军医大学病理学教研室

摘要

应用抗ＨＣＶＣ＿（３３ｃ）抗原２Ｂ６株单克隆抗体和抗ＨＢｘＡｇ多克隆抗体。以ＡＢＣ法对８６例肝硬变组织进行ＨＣＶ及ＨＢＶ相关抗原定位研究，ＨＣＶＣ＿（３３ｃ）抗原及ＨＢｘＡｇ在肝硬变中的阳性率分别为７６．７％及６２．８％，Ｃ＿（３３ｃ）抗原和ＨＢｘＡｇ阳性占所检病例８８．４％，二者同时阳性为５１．２％，ＨＣＶＣ＿（３３ｃ）抗原位于肝硬变组织的肝细胞胞桨内，充满整个胞桨，细胞核及胞膜未见阳性；阳性细胞呈弥漫、局灶及散在分布三种形式，以弥漫、局灶分布为主。部分病例阳性细胞周围有较多的淋巴细胞、单核细胞浸润。并发现ＨＣＶＣ＿（３３ｃ）抗原位于小胆管上皮细胞内。结果提示ＨＣＶ感染致肝细胞损伤可能是免疫反应参与的免疫损害。除ＨＢＶ以外，ＨＣＶ感染在我国肝硬变发生中起一定作用，在肝硬变组织中ＨＣＶ、ＨＢＶ重叠感染较为普遍。
- 丙型肝炎病毒
- , 乙型肝炎病毒
- , 肝硬变
- , 抗原

Detection of the HCV C(33c) Antigen and HBxAg in Liver Cirrhositic Tissues by Immunohistochemical Techniques

1.
Department of Pathology

Abstract

The HCV C_(33c) antigen and HBxAg were detected with monoclonal antibod ies against C_(33C) and Poly-clonal antibedies agalnst HBxAg by immunohistochemical techniquee in 86 paraffin-embeded sectionsof liver cirrhositic tissues,The rate of the HCV C_(33c) antigen and HBxAg positive was 76.7%(66/86)anct 62.8%(54/86)respectively.The rate of either the HCV C_(33c) or HBxAg positive was 88.4%(76/86).The rate of both the HCV C_(33C) and HBxAg positive was 51.2%(44/86).The HCV C_(33c) antigenwas clearly stained in ...
- Hepatitis C Virus（HCV）
- , Hepatitis B Virus（HBV）
- , Liver cirrhosis
- , Antigen

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Detection of the HCV C(33c) Antigen and HBxAg in Liver Cirrhositic Tissues by Immunohistochemical Techniques

1. Department of Pathology

Abstract: The HCV C_(33c) antigen and HBxAg were detected with monoclonal antibod ies against C_(33C) and Poly-clonal antibedies agalnst HBxAg by immunohistochemical techniquee in 86 paraffin-embeded sectionsof liver cirrhositic tissues,The rate of the HCV C_(33c) antigen and HBxAg positive was 76.7%(66/86)anct 62.8%(54/86)respectively.The rate of either the HCV C_(33c) or HBxAg positive was 88.4%(76/86).The rate of both the HCV C_(33C) and HBxAg positive was 51.2%(44/86).The HCV C_(33c) antigenwas clearly stained in ...