A Study on the Relation between Changes of lnterleukin and Receptor in Serum in Patients with Chronic Hepatitis B and Action of Treatment with IFN．a

HE Sheng-Song; LI Chu-Chi; XIONG Chi-Juan; LIU Wei; CENG Lian-Lan

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August 2000

HE Sheng-Song, LI Chu-Chi, XIONG Chi-Juan, LIU Wei and CENG Lian-Lan. A Study on the Relation between Changes of lnterleukin and Receptor in Serum in Patients with Chronic Hepatitis B and Action of Treatment with IFN．a[J]. Virologica Sinica, 2000, 15(4): 342-345.

Citation: HE Sheng-Song, LI Chu-Chi, XIONG Chi-Juan, LIU Wei, CENG Lian-Lan. A Study on the Relation between Changes of lnterleukin and Receptor in Serum in Patients with Chronic Hepatitis B and Action of Treatment with IFN．a .VIROLOGICA SINICA, 2000, 15(4) : 342-345.

IFN-治疗慢性乙肝抗病毒疗效与细胞因子变化关系分析

1.
同济医科大学附属协和医院传染科，武汉430022

摘要

观察慢性乙型病毒性肝炎 (CHB)患者 ( 2 5例 )经干扰素 (IFN )抗病毒治疗前后血清中细胞因子和受体水平的变化与乙肝病毒消长之间的关系。收集治疗前后血清标本ELISA法同步检测 ,根据治疗后乙肝病毒复制指标 (HBV DNA)阴转分应答组 ( 10例 )与无应答组 ( 15例 )进行统计学分析。治疗后两组血清中IL 6水平下降 ,尤其应答组下降明显 ;治疗后应答组IL 2水平明显升高 (P 0 .0 1) ,sIL 2R水平则明显下降 ;但治疗后两组TNF 均较治疗前下降 ,相反IL 8水平升高接近正常人水平 ;CHB患者体内存在免疫功能的失调 ,通过IFN 免疫调节 (IL 6、IL 2、sIL 2R)对病毒复制影响具有重要作用。但TNF 和IL 8表达与病毒复制消长无相关关系
- 慢性乙型病毒性肝炎
- , 白细胞介素
- , 肿瘤坏死因子-
- , -干扰素

A Study on the Relation between Changes of lnterleukin and Receptor in Serum in Patients with Chronic Hepatitis B and Action of Treatment with IFN．a

1.
Department of Infectious Disease， Union Hospita1，Tongii Medical University．Wuhan 430022．China

Abstract

Objective\ To study the relationship between the changes of Interleukin and Receptor in serum of patients with chronic hepatitis B (CHB) before and after Interferon (IFN ) treatment and expression of HBV marker. Methods: Enzyme liked immunosorbent assay (ELISA) were performed in 25 patients with CHB to determine levels of IL 6\, IL 2\,TNF \, IL 8\, sIL 2R in serum. Results: Our date showed that the IL 6 level in response group after IFN treatment was significantly lower than that befor (P0.05). The level of IL 2 in unresponse group after IFN treatment was significantly decreased, but the level in response group was significantly increased (P0.01), but the serum sIL 2R level in patients with response was significantly decreased (P0.01). The TNF level in both response and unresponse group after IFN treatment was significantly decreased (P0.01), but the serum IL 8 level was increased. Conclusion\ The results suggest that HBV replication in patients with CHB could be also affected
- Chronic Hepatitis B Interleukin（IL）
- , Tumor necrosis factor （TNF ）
- , Interferon （IFN ）

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

A Study on the Relation between Changes of lnterleukin and Receptor in Serum in Patients with Chronic Hepatitis B and Action of Treatment with IFN．a

1. Department of Infectious Disease， Union Hospita1，Tongii Medical University．Wuhan 430022．China

Abstract: Objective\ To study the relationship between the changes of Interleukin and Receptor in serum of patients with chronic hepatitis B (CHB) before and after Interferon (IFN ) treatment and expression of HBV marker. Methods: Enzyme liked immunosorbent assay (ELISA) were performed in 25 patients with CHB to determine levels of IL 6\, IL 2\,TNF \, IL 8\, sIL 2R in serum. Results: Our date showed that the IL 6 level in response group after IFN treatment was significantly lower than that befor (P0.05). The level of IL 2 in unresponse group after IFN treatment was significantly decreased, but the level in response group was significantly increased (P0.01), but the serum sIL 2R level in patients with response was significantly decreased (P0.01). The TNF level in both response and unresponse group after IFN treatment was significantly decreased (P0.01), but the serum IL 8 level was increased. Conclusion\ The results suggest that HBV replication in patients with CHB could be also affected