Genotyping of Hepatitis C Virus in Hebei Province

NIU Jian; XU Ruo; BAI Rui; TIAN Cha; ZHANG Li-ping; M ENG

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December 2003

NIU Jian, XU Ruo, BAI Rui, TIAN Cha, ZHANG Li-ping and M ENG. Genotyping of Hepatitis C Virus in Hebei Province[J]. Virologica Sinica, 2003, 18(6): 611-613.

Citation: NIU Jian, XU Ruo, BAI Rui, TIAN Cha, ZHANG Li-ping, M ENG. Genotyping of Hepatitis C Virus in Hebei Province .VIROLOGICA SINICA, 2003, 18(6) : 611-613.

河北省丙型肝炎病毒基因分型研究

1.
1 河北大学生命科学学院，河北保定，071002
2.
河北省疾病预防控制中心，河北石家庄。050011

摘要

丙型肝炎病毒(Hepatitis C virus，HCV)感染是输血后肝炎的主要原因，主要通过输血或使用污染的血制品传播【2】，且与肝硬化和肝细胞癌的发生有密切关系。1985年河北省在国内首先报告了丙型肝炎的爆发流行【2】，此后，在HCV的病源学【3】、流行病学【4】和检测技术[51等方面进行了较深入的研究，取得了一批重要的研究成果。1991年美、日学者先后报告了HCV的全基因序列，为基因分型研究奠定了重要基础。Okamoto等[6．71根据HCV核心区基因序列的不同，设计型特异性引物，用巢式 RT．PCR方法，将HCV分为I(1a)、II(1b)、III(2a)、 IV(2b)4型。为了探讨河北省HCV基因型分布，为病毒性肝炎的防治提供科学依据，本文对河北省HCV 基因型分布进行了研究。
- 丙型肝炎病毒
- , 基因分型：巢式RT—PCR

Genotyping of Hepatitis C Virus in Hebei Province

1.
College of Life Sciences，Hebei University,Baoding 071002，China
2.
Center ofDisease Control,Hebei Province, shijiazhuang 050011,China

Abstract

Abstract：Using nested RT—PCR an d type special primers of HCV,we performed genotype an alysis of HCV RNA from five representative cities in Hebei Province．Among 168 samples with HCV RNA，104 sera was typelb(61．9％)，type 2a account for 22．6％ (38／168)，and lb／2a mixed—type was 15．5％ (26／168)．The results indicate that typelb is the dominance strain in Hebei Province．Compared with type 2a，type lb has important relationship with chronic hepatitis C．This study build 叩some foundations for diagnosis，treatment and vaccine study of hepatitis C．
- Hepatitis C virus(HCV)
- , Genotyping

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Genotyping of Hepatitis C Virus in Hebei Province

1. College of Life Sciences，Hebei University,Baoding 071002，China
2. Center ofDisease Control,Hebei Province, shijiazhuang 050011,China

Abstract: Abstract：Using nested RT—PCR an d type special primers of HCV,we performed genotype an alysis of HCV RNA from five representative cities in Hebei Province．Among 168 samples with HCV RNA，104 sera was typelb(61．9％)，type 2a account for 22．6％ (38／168)，and lb／2a mixed—type was 15．5％ (26／168)．The results indicate that typelb is the dominance strain in Hebei Province．Compared with type 2a，type lb has important relationship with chronic hepatitis C．This study build 叩some foundations for diagnosis，treatment and vaccine study of hepatitis C．