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Citation: Jun Zhuang, Wenwu Lin, Christopher J. Coates, Pengxiang Shang, Taiyun Wei, Zujian Wu, Lianhui Xie. Cleavage of the Babuvirus Movement Protein B4 into Functional Peptides Capable of Host Factor Conjugation is Required for Virulence [J].VIROLOGICA SINICA.  http://dx.doi.org/10.1007/s12250-019-00094-4

Cleavage of the Babuvirus Movement Protein B4 into Functional Peptides Capable of Host Factor Conjugation is Required for Virulence

  • Corresponding author: Jun Zhuang, fafuzj@126.com Lianhui Xie, fjxlh@126.com
  • Accepted Date: 22 March 2019
    Published Date: 22 March 2019
  • Banana bunchy top virus (BBTV) poses a serious danger to banana crops worldwide. BBTV-encoded protein B4 is a determinant of pathogenicity. However, the relevant molecular mechanisms underlying its effects remain unknown. In this study, we found that a functional peptide could be liberated from protein B4, likely via proteolytic processing. Site-directed mutagenesis indicated that the functional processing of protein B4 is required for its pathogenic effects, including dwarfism and sterility, in plants. The released protein fragment targets host proteins, such as the large subunit of RuBisCO (RbcL) and elongation factor 2 (EF2), involved in protein synthesis. Therefore, the peptide released from B4 (also a precursor) may act as a non-canonical modifier to influence host–pathogen interactions involving BBTV and plants.
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    Cleavage of the Babuvirus Movement Protein B4 into Functional Peptides Capable of Host Factor Conjugation is Required for Virulence

      Corresponding author: Jun Zhuang, fafuzj@126.com
      Corresponding author: Lianhui Xie, fjxlh@126.com
    • 1. State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    • 2. Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    • 3. Department of Biosciences, College of Science, Swansea University, Swansea SA2 8PP, Wales, UK

    Abstract: Banana bunchy top virus (BBTV) poses a serious danger to banana crops worldwide. BBTV-encoded protein B4 is a determinant of pathogenicity. However, the relevant molecular mechanisms underlying its effects remain unknown. In this study, we found that a functional peptide could be liberated from protein B4, likely via proteolytic processing. Site-directed mutagenesis indicated that the functional processing of protein B4 is required for its pathogenic effects, including dwarfism and sterility, in plants. The released protein fragment targets host proteins, such as the large subunit of RuBisCO (RbcL) and elongation factor 2 (EF2), involved in protein synthesis. Therefore, the peptide released from B4 (also a precursor) may act as a non-canonical modifier to influence host–pathogen interactions involving BBTV and plants.

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