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Citation: Ziming Wang,  Lijia Jia,  Jing Li,  Haizhou Liu,  Di Liu. Pan-Genomic Analysis of African Swine Fever Virus [J].VIROLOGICA SINICA.  http://dx.doi.org/10.1007/s12250-019-00173-6

Pan-Genomic Analysis of African Swine Fever Virus

  • Corresponding author: Di Liu, liud@wh.iov.cn
  • Received Date: 10 September 2019
    Accepted Date: 17 October 2019
    Published Date: 11 December 2019

    Fund Project: This work was supported by grants from the National Key Research and Development Program of China (2018YFC1603803, 2018YFC0840402 and 2016YFC1200800) and the Research Project of African Swine Fever of Chinese Academy of Sciences (KJZD-SW-L06).

  • African swine fever (ASF) is a severe haemorrhagic fever in domestic pigs and wild boar with extremely high mortality rate. It is cataloged as a notifiable disease by the World Organization for Animal Health (OIE). The etiological agent that causes the highly lethal disease is the African swine fever virus (ASFV) (Sanchez-Vizcaino et al. 2015). ASFV is the only known member of the genus Asfivirus and family Asfarviridae. The family Asfarviridae belongs to the member of nucleocytoplasmic large DNA viruses (NCLDV) superfamily (Iyer et al. 2006; Costard et al. 2009). Overall, the ASFV virion presents an icosahedral morphology with a multilayered structure (Wang et al. 2019). The genome of ASFV is a large doublestranded DNA (dsDNA) molecule that varies in length from about 170 to 193 kilobase pairs and encodes between 150 and 167 open reading frames (ORFs) depending on the isolate (Dixon et al. 2013). In addition, ASFV also infects African wild suids, including warthogs (Phacochoerus africanus) and bushpigs (Potamochoerus larvatus), which act as asymptomatic carriers. Soft ticks of the Ornithodoros moubata complex also serve as a natural reservoir and transmit the disease to suids. In East Africa, ASFV is maintained in an ancient sylvatic cycle involving warthogs and soft ticks (Ornithodoros genus) that inhabit their burrows (Jori et al. 2013).

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    Pan-Genomic Analysis of African Swine Fever Virus

      Corresponding author: Di Liu, liud@wh.iov.cn
    • 1 CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    • 2 Computational Virology Group, Center for Bacteria and Virus Resources and Bioinformation, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    • 3 University of Chinese Academy of Sciences, Beijing 100049, China
    • 4 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    • 5 African Swine Fever Regional Laboratory of China, Wuhan 430071, China
    • 6 Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China
    Fund Project:  This work was supported by grants from the National Key Research and Development Program of China (2018YFC1603803, 2018YFC0840402 and 2016YFC1200800) and the Research Project of African Swine Fever of Chinese Academy of Sciences (KJZD-SW-L06).

    Abstract: African swine fever (ASF) is a severe haemorrhagic fever in domestic pigs and wild boar with extremely high mortality rate. It is cataloged as a notifiable disease by the World Organization for Animal Health (OIE). The etiological agent that causes the highly lethal disease is the African swine fever virus (ASFV) (Sanchez-Vizcaino et al. 2015). ASFV is the only known member of the genus Asfivirus and family Asfarviridae. The family Asfarviridae belongs to the member of nucleocytoplasmic large DNA viruses (NCLDV) superfamily (Iyer et al. 2006; Costard et al. 2009). Overall, the ASFV virion presents an icosahedral morphology with a multilayered structure (Wang et al. 2019). The genome of ASFV is a large doublestranded DNA (dsDNA) molecule that varies in length from about 170 to 193 kilobase pairs and encodes between 150 and 167 open reading frames (ORFs) depending on the isolate (Dixon et al. 2013). In addition, ASFV also infects African wild suids, including warthogs (Phacochoerus africanus) and bushpigs (Potamochoerus larvatus), which act as asymptomatic carriers. Soft ticks of the Ornithodoros moubata complex also serve as a natural reservoir and transmit the disease to suids. In East Africa, ASFV is maintained in an ancient sylvatic cycle involving warthogs and soft ticks (Ornithodoros genus) that inhabit their burrows (Jori et al. 2013).

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