Tilorone confers robust <em>in vitro</em> and <em>in vivo</em> antiviral effects against severe fever with thrombocytopenia syndrome virus

Jingjing Yang; Yunzheng Yan; Qingsong Dai; Jiye Yin; Lei Zhao; Yuexiang Li; Wei Li; Wu Zhong; Ruiyuan Cao; Song Li

doi:10.1016/j.virs.2022.01.014

February 2022

Citation: Jingjing Yang, Yunzheng Yan, Qingsong Dai, Jiye Yin, Lei Zhao, Yuexiang Li, Wei Li, Wu Zhong, Ruiyuan Cao, Song Li. Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus .VIROLOGICA SINICA, 2022, 37(1) : 145-148. http://dx.doi.org/10.1016/j.virs.2022.01.014

Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus

Jingjing Yang ^a,b ,
Yunzheng Yan ^b ,
Qingsong Dai ^b ,
Jiye Yin ^b ,
Lei Zhao ^b ,
Yuexiang Li ^b ,
Wei Li ^b ,
Wu Zhong ^b ,
Ruiyuan Cao ^{b
,,} ,
Song Li ^{a,b
,,}

a School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China
b National Engineering Research Centre for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China

Corresponding author: Ruiyuan Cao, 21cc@163.com
Song Li, lis.lisong@gmail.com
Received Date: 08 September 2021
Accepted Date: 25 November 2021
Available online: 18 January 2022

Abstract

Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging pathogen, is a tick-borne bunyavirus belonging to the genus Bandavirus in the family Phenuiviridae (Kuhn et al., 2020). This pathogen was first identified in China during the heightened surveillance of acute febrile illness in 2009, and has been reported to cause several outbreaks in eastern Asia areas, including China, Japan, and Korea (Yu et al., 2011). Besides, Vietnam has also reported several confirmed SFTS cases (Tran et al., 2019). The mortality rate in hospitalised patients with SFTSV infection is up to 10%–30%. Moreover, SFTSV has been reported to possibly transmitted by the contact of body fluids from person-to-person, and extensive SFTSV contamination was detected in the patient rooms (Kim et al., 2015). These reports suggest that more stringent isolation measures are needed for the prevention of massive SFTSV outbreak.

Electronic Supplementary Material

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