Viral hemorrhagic fevers are caused by several distinct families of RNA and DNA viruses that can cause devastating disease in humans and other animals. Hemorrhagic fever viruses usually reside in animal or arthropod hosts and transmit to humans, resulting in human outbreak. Four major families of HFVs are Arenaviridae, Filoviridae, Bunyaviridae, and Flaviviridae. This special Issue presents the recent progress on Ebola virus, dengue virus, hantavirus, Crimean-Congo hemorrhagic fever virus, severe fever with thrombocytopenia syndrome virus, and covers topics on viral epidemiology, viral pathogenesis, and virus-host cell interaction of those hemorrhagic fever viruses. The cover depicts the hemorrhagic fever viruses and their major hosts.
It is both an honor and pleasure to have been appointed as the Editor-in-Chief of the journal Virologica Sinica from this volume. Professor Xinwen CHEN, who has dedicated to serve the journal as the Editor-in-Chief for 15 years, concluded his term of service in the last volume. I would like to thank Prof.
肾综合征出血热（hemorrhagic fever with renal syndrome，HFRS）由汉坦病毒感染引起，我国是高发地区。β3整合素为致病性汉坦病毒在易感细胞上的主要受体，由β3亚基参与组成的整合素有αVβ3和αIIbβ3两种。既往研究表明整合素αIIbβ3的单核苷酸多态性（SNP）与汉坦病毒感染有一定关联性，而整合素αVβ3 SNP与汉坦病毒感染的关联性未见报道。本实验采用TaqMan SNP基因分型探针实时定量PCR和双向等位基因特异性PCR（BI-PASA）两种方法对整合素αVβ3 SNP rs5918、rs3768777、rs3738919、rs13306487、rs5921进行基因分型，研究整合素αVβ3 SNP 与HV感染的关联性。结果发现湖北地区汉族人群中HFRS患者整合素αVβ3五个位点的单核苷酸基因多态性与汉坦病毒感染易感性及疾病严重程度无关联性。